The role of cohesin in genome 3D structure helps for a better understanding of tumor cells

(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) The genome spatial organization depends on a number of factors, the cohesin protein complex being one of them. This essential complex is present in two versions that contain either the SA1 or SA2 subunit. A study analyses in-depth the functions of both variants in 3D genome architecture and shows how the alteration of SA2 influences gene expression and may favor the loss of differentiation in tumor cells.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news