NCI-MATCH precision medicine clinical trial releases new findings, strengthens path forward for targeted cancer therapies

Results could play a role in bringing targeted treatments to patients with certain gene abnormalities, regardless of their cancer type.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news

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Cell death pathologies: targeting death pathways and the immune system for cancer therapy, Published online: 19 December 2018; doi:10.1038/s41435-018-0052-xCell death pathologies: targeting death pathways and the immune system for cancer therapy
Source: Genes and Immunity - Category: Genetics & Stem Cells Authors: Source Type: research
Nanoscale metal –organic frameworks‐based nanohybrids capable of protecting prodrugs from degradation are engineered for photodynamic therapy and hypoxia ‐triggered cascade chemotherapy. The nanovehicles with good stability, favorable photodynamic therapy (PDT) performance, and on‐demand prodrug release take advantage of the hypoxia generated by PDT to activate cascade chemotherapy, achieving enhanced tumor suppression as well as negligible syste mic toxicity. AbstractDuring photodynamic therapy (PDT), severe hypoxia often occurs as an undesirable limitation of PDT owing to the O2‐consuming photodynamic proce...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
High-glucose promotes proliferation of human bladder cancer T24 cells by activating Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 2018 Dec;22(23):8151-8160 Authors: Gao L, Xu FM, Shi WJ, Zhang S, Lu YL, Zhao DK, Long YF, Teng RB, Ge B Abstract OBJECTIVE: Bladder cancer is the most prevalent genitourinary malignant disorder worldwide. We aimed to observe effects of high-glucose on bladder cancer proliferation and explore the associated mechanisms. MATERIALS AND METHODS: Human bladder cancer cell line, T24, was divided into Blank, Control (Ctrl), 10 mmol/l, 20 mmol/l and 30 mmol/l ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Fortunately>80% of children diagnosed with cancer become long-term survivors; however, this population is at a significantly increased risk of morbidity and mortality as a result of their previous cancer therapy, and long-term follow-up (LTFU) is critical. Multiple barriers to receiving adequate LTFU care have been studied. We investigated whether lack of enrollment in a therapeutic clinical trial may be a barrier to receiving LTFU care. We conducted a review of 353 patient records at the Children’s Hospital of Michigan enrolled in our Children’s Oncology Group registry between January 1, 2005 and December 3...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
ConclusionsDependent on dose, RSV activated either anti-fibrotic or pro-fibrotic effects in kidneys. The risk of RSV consumption in individuals with impaired kidney function should be carefully considered.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
The National Cancer Institute in Rockville, Maryland, has opened an innovative clinical trial for patients with peritoneal mesothelioma that will explore the safety and effectiveness of a novel CAR T-cell therapy. The phase I trial also is being conducted at Washington University in St. Louis. It is aimed at patients whose disease has relapsed after initial chemotherapy treatment. It involves a laboratory modification of a patient’s T cells — a type of white blood cell — that can help the immune system kill the cancer. CAR T-cell therapy is a form of gene therapy that has been highly successful with blood...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
AbstractThe androgen-directed treatment of prostate cancer (PCa) is fraught with the recurrent profile of failed treatment due to drug resistance and must be addressed if we are to provide an effective therapeutic option. The most singular difficulty in the treatment of PCa is the failure to respond to classical androgen withdrawal or androgen blockade therapy, which often develops as the malignancy incurs genetic alterations and gain-of-function somatic mutations in the androgen receptor (AR). Physical cellular damaging therapeutic agents, such as radiation or activatable heat-generating transducers would circumvent class...
Source: Hormones and Cancer - Category: Cancer & Oncology Source Type: research
Abstract Multifunctional nanohybrids are attracting increasing attention for potential biomedical applications such as bioimaging and drug delivery due to their combined advantages of individual components. However, challenges in the improvement of their synthesis and colloidal stability to facilitate practical biomedical applications still remain. In this work, we report an efficient synthetic approach to fabricate magnetofluorescent nanohybrid (IO-PG-CD) comprising fluorescent carbon dots (CDs) and magnetic iron oxide nanoparticles (IOs) through polyglycerol (PG) mediated covalent linkage in aqueous media. CDs a...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research
New J. Chem., 2019,43,217-229 DOI: 10.1039/C8NJ03350A, PaperDipranjan Laha, Kunal Pal, Angshuman Ray Chowdhuri, Pravat Kumar Parida, Sumanta Kumar Sahu, Kuladip Jana, Parimal Karmakar Curcumin has shown therapeutic activity against triple-negative breast cancer (TNBC) cells, but it shows low efficacy and low bioavailability when administered as a free drug. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.8b00924
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
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