Amphetamine improves mouse and human attention in the 5-choice continuous performance test.
Amphetamine improves mouse and human attention in the 5-choice continuous performance test.
Neuropharmacology. 2018 May 31;:
Authors: MacQueen DA, Minassian A, Kenton JA, Geyer MA, Perry W, Brigman JL, Young JW
Abstract
Non-medical use of prescription stimulants amongst college students is common, with claims of cognitive and academic benefits. The mechanism, magnitude, and pervasiveness of the cognitive enhancing effects of stimulants in healthy adults remain poorly understood however. The present study determined the effects of dextroamphetamine (D-amp) on the 5-choice continuous performance test (5C-CPT) of attention in healthy young adult humans and mice. A mixed gender sample received placebo (n = 29), 10 (n = 17) or 20 mg D-amp (n = 25) in a double-blind fashion before 5C-CPT testing. In addition, male C57BL/6J mice were trained on a touchscreen adaptation of the 5C-CPT and tested after receiving saline or D-amp (0.1, 0.3, 1.0 mg/kg; n = 8/dose). In humans, D-amp significantly improved 5C-CPT performance. Both doses improved signal detection driven by increased hit rate (reduced omissions). Both doses also improved response accuracy and reduced hit reaction time (HRT) variability. In mice, similar effects (improved signal detection, hit rate, and response accuracy) were observed at the moderate dose (0.3 mg/kg). In contrast to human participants however, no effect on HRT variability was detected in mice, w...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: MacQueen DA, Minassian A, Kenton JA, Geyer MA, Perry W, Brigman JL, Young JW Tags: Neuropharmacology Source Type: research
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