B-cell activating factor and related genetic variants in lupus related atherosclerosis.

CONCLUSIONS: High BAFF serum levels in the upper 4th quartile as well as BAFF genetic variants seem to increase susceptibility for both lupus and lupus related subclinical atherosclerosis implying B-cell hyperactivity as a potential contributor in the pronounced lupus related atherosclerotic risk.
PMID: 29859654 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - May 30, 2018 Category: Allergy & Immunology Authors: Theodorou E, Nezos A, Antypa E, Ioakeimidis D, Koutsilieris M, Tektonidou M, Moutsopoulos HM, Mavragani CP Tags: J Autoimmun Source Type: research