A Sarcoidosis Clinician's Perspective of MHC Functional Elements Outside the Antigen Binding Site.
A Sarcoidosis Clinician's Perspective of MHC Functional Elements Outside the Antigen Binding Site. Hum Immunol. 2018 May 30;: Authors: Judson MA Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause. Evidence supports an integral role for interactions at the MHC binding site in the development of sarcoidosis. However, despite this evidence, there are clinical data that suggest that additional mechanisms are involved in the immunopathogenesis of this disease. This manuscript provides a brief clinical description of sarcoidosis, and a clinician's perspective of the immunopathogenesis of sarcoidosis in terms of the MHC binding site, MHC functional elements beyond the binding site, and other possible alternative mechanisms. Input from clinicians will be essential in establishing the immunologic cause of sarcoidosis as a detailed phenotypic characterization of disease will be required. PMID: 29859205 [PubMed - as supplied by publisher]
Condition: Cardiac Sarcoidosis Intervention: Diagnostic Test: hybrid PET/MRI Sponsor: University of Alabama at Birmingham Not yet recruiting
ConclusionRadiological imaging studies are insufficient for the differential diagnosis of splenic lesions in sarcoidosis from other diseases, whereas laparoscopic splenectomy is less invasive and useful as part of the diagnostic approach.
Sclerosing orbital lesion(the biopsy revealed it to be Erdheim-Chester disease)Sclerosing lesions of the orbit can present a diagnostic conundrum. Often submitted with a differential diagnosis that includes idiopathic sclerosing pseudotumor, it is incumbent upon the pathologist to rule out other diagnostic possibilities before designating the lesion as idiopathic. In order to survey the range of diagnoses for such specimens, we searched over a 10-year period for specimens submitted to the University of Colorado pathology department which either clinically or pathologically raised the possibility of idiopathic sclerosing ps...
Sarcoidosis is a multisystem systemic disorder, characterised histologically by non caseating granulomas. It most commonly presents with involvement of the lungs or mediastinal lymph nodes, but may have liver, cardiac, joint, skin, neurological and eye manifestations. 5 - 20% of subjects with systemic sarcoidosis have eye involvement, most commonly dry eye or uveitis.1
Publication date: Available online 15 April 2019Source: Respiratory Medicine Case ReportsAuthor(s): Asma Iftikhar, Muhammad A.I. Cheema, Preethi Ramachandran, Sonu SahniAbstractRenal cell carcinoma (RCC) is a highly vascular tumor, which may spread to the lungs and other organs. It often presents with localized or systemic manifestation, including paraneoplastic syndromes. Sarcoidosis is a systemic granulomatous inflammatory disease characterized by non-caseating granulomas that typically afflicts the respiratory system. In the absence of any evidence of systemic sarcoidosis they are referred to as sarcoid-like reactions. ...
Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects the lungs in 90% of patients, but has a wide range of disease manifestations and outcomes including chronic and progressive courses. Noninvasive biomarkers are needed to assess these outcomes and guide decisions for long term monitoring and treatment. Interferon-gamma (IFN- γ)-inducible chemotactic cytokines (chemokines), CXCL9, CXCL10 and CXCL11, show promise in this regard because they have been implicated in the pathogenesis of and reflect the burden of granulomatous inflammation.
AbstractTwo cases of misdiagnoses of lymphomatoid granulomatosis are discussed here. Lymphomatoid granulomatosis is an Epstein-Barr virus-associated lymphoproliferative disorder with aggressive behavior. Due to its rarity and many presentations, delay in diagnosis and treatment is common. Its histological features including large atypical B-cells, T cell predominance, angiocentricity, necrosis, and evidence of EBV-positive cells should elicit the diagnosis of lymphomatoid granulomatosis. The settings that are described here have not yet been described in the literature.
Conditions: Sarcoidosis, Pulmonary; Telerehabilitation Intervention: Behavioral: Telerehabilitation Sponsors: Aarhus University Hospital; Eurostars; University of Aarhus Recruiting
In conclusion, we describe the genetic and epidemiological traits of several novel APVs discovered in six different bird species, some of which were not previously known to harbor PVs. We demonstrate that the genome organization of all currently known APVs is very similar and that there is some synteny in the phylogenetic relationships of APVs and their avian hosts, with evidence for virus–host co-divergence. Cross-species transmission events seem to occur between genetically closely related hosts and our findings show how host behavior can affect viral ecology and evolution. Ethics Statement This study was carried...