A Sarcoidosis Clinician's Perspective of MHC Functional Elements Outside the Antigen Binding Site.

A Sarcoidosis Clinician's Perspective of MHC Functional Elements Outside the Antigen Binding Site. Hum Immunol. 2018 May 30;: Authors: Judson MA Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause. Evidence supports an integral role for interactions at the MHC binding site in the development of sarcoidosis. However, despite this evidence, there are clinical data that suggest that additional mechanisms are involved in the immunopathogenesis of this disease. This manuscript provides a brief clinical description of sarcoidosis, and a clinician's perspective of the immunopathogenesis of sarcoidosis in terms of the MHC binding site, MHC functional elements beyond the binding site, and other possible alternative mechanisms. Input from clinicians will be essential in establishing the immunologic cause of sarcoidosis as a detailed phenotypic characterization of disease will be required. PMID: 29859205 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research

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Conclusion: Peptide receptor radionuclide therapy in sarcoidosis is feasible and might be a new valuable tool in patients with otherwise treatment-refractory disease. Given the long experience with and good tolerability of PRRT, further evaluation of this new treatment option for otherwise treatment-refractory sarcoidosis in larger patient cohorts is warranted.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conditions:   Sarcoidosis;   Cardiomyopathies Interventions:   Diagnostic Test: 18F-FDG-PET/MRI;   Diagnostic Test: 18F-GE180-PET/MRI Sponsors:   St. Olavs Hospital;   Norwegian University of Science and Technology;   University Hospital, Essen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsThis prospective study of neurosarcoidosis increases our understanding of the pathophysiology of the disease. A reclassification of the clinical and imaging features of the disease allows an understanding of its pathophysiology and correlation with CSF indices allows an early identification of those with a more destructive disease will help to define treatment and may thereby improve outcome.
Source: Journal of Neurology - Category: Neurology Source Type: research
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Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
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Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
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Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Chronic pulmonary aspergillosis (CPA) is a slowly progressive infection mainly caused by Aspergillus fumigatus, characterized by inflammatory destruction of lung tissue with cavitation, pleural thickening and/or fibrosis, and associated with significant respiratory and constitutional symptoms [1 –3]. CPA usually affects patients with underlying structural airway disease with air-filled cavities or bullae, such as tuberculosis (TB), non-tuberculous mycobacterial infection, chronic obstructive pulmonary disease (COPD), allergic bronchopulmonary aspergillosis (ABPA), pneumothorax and sarcoid osis.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research
Nephrology,Volume 23, Issue 6, Page 597-600, June 2018.
Source: Nephrology - Category: Urology & Nephrology Authors: Source Type: research
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Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Condition:   Cardiac Sarcoidosis Interventions:   Drug: 68Ga-DOTATATE PET/CT;   Drug: 18FDG PET/CT scan;   Drug: 13NH3 PET/CT scan Sponsor:   Mayo Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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