Time to deliver: report of the WHO Independent High-Level Commission on NCDs

This paper provides possible policy options and interventions on NCDs. Main NCDs include CVD, cancers, chronic respiratory diseases, and diabetes; these are largely preventable through public policies that tackle risk factors - tobacco, alcohol, unhealthy diet, and inactivity.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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ConclusionsIn conclusion, DM may be associated with an increased risk of colorectal cancer in non-menopausal women and a decreased risk of prostate cancer and all cancers combined.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewPancreatic cancer remains one of the most lethal of malignancies with 5-year survival of only 8%. A number of reasons account for the high fatality rate including few known modifiable risk factors, no effective screening tools, and lack of early diagnostic symptoms. Therefore, in this review, we aim to summarize existing evidence from major studies concerning (1) risk factors for risk assessment and risk stratification, and (2) screening modalities and early detection markers to better understand the ways to prevent pancreatic cancer or identify it at earlier stages. Improvements in primary and sec...
Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
Prevention is often called the best medicine — but research has shown that millions of Americans are not getting the preventive care they should to live long, healthy lives. Obstacles like inadequate access to care and financial barriers can keep people away from the doctor, but anxiety and feeling like care is unnecessary are also common deterrents. “There are a lot of things that every person could do to stay healthy, and this could help people to feel better, improve their quality of life and help them to live longer,” says Dr. Alex Krist, a professor of family medicine at Virginia Commonwealth Univer...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Longevity public health Source Type: news
The objective of this study was to assess the relative contribution of a wider range of risk factors in the development of CIPN.MethodsThis analysis used the 6 ‐month data after starting chemotherapy from a larger prospective observational study on CIPN risk, prevalence, and quality of life. Patients were assessed at recruitment for possible CIPN risk factors, including prior history of neuropathies, current/past infectious diseases; neurotoxic medicatio n history; personal and treatment characteristics; smoking history, alcohol use, and vegetable/fruit intake. Neuropathy was assessed at 6‐months after starting chemoth...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
This study examined the attitudes, experiences, and willingness of persons of African descent related to participation in genetic research. A total of 272 persons of African descent completed a questionnaire about attitudes and experiences associated with genetic research. Descriptive, Chi-square, and logistic regression were used to examine the impact of attitudes and experiences in predicting the odds of willingness to participate in genetic research. A majority of participants (97%) indicated that they have never participated in genetic research; however, a majority also reported that they would be willing to participat...
Source: Journal of Community Genetics - Category: Genetics & Stem Cells Source Type: research
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an as...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractCoffee consumption has been associated with decreased mortality in previous studies. As aging, obesity, and lifestyle factors affect the risk of mortality, the association between coffee and mortality needs to be examined in various subpopulations by characteristics of subjects. To quantitatively assess this association, we conducted an updated meta-analysis including stratified analyses by potential modifiers. We searched in the PubMed and Web of Science databases through March 8, 2019, and conducted meta-analysis including linear and non-linear dose –response analyses. We identified 40 studies including 3,8...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
Filomena Corbo1†, Giacomina Brunetti2*†, Pasquale Crupi3, Sara Bortolotti4, Giuseppina Storlino4, Laura Piacente5, Alessia Carocci1, Alessia Catalano1, Gualtiero Milani1, Graziana Colaianni4, Silvia Colucci2, Maria Grano4, Carlo Franchini1, Maria Lisa Clodoveo6, Gabriele D'Amato7 and Maria Felicia Faienza5 1Department of Pharmacy-Drug science, University of Bari Aldo Moro, Bari, Italy 2Section of Human Anatomy and Histology, Department of Basic and Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy 3CREA-VE, Council for Agricultural Research and Economics&ndas...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: Overall, this study provides a high accurate approach to predict HILI and an in silico perspective into understanding the hepatotoxicity mechanism of TCM, which might facilitate the discovery and development of new drugs. Introduction Liver injury induced by drug, novel foods or phytotherapy, also known as hepatotoxicity, is still a major clinical and pharmaceutical concern (Amadi and Orisakwe, 2018; Hammann et al., 2018; Kyawzaw et al., 2018; Real et al., 2018). According to the data from United States National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), hepatotoxicity accounts for...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Bianca Cox1†, Maria Tsamou1†, Karen Vrijens1, Kristof Y. Neven1, Ellen Winckelmans1, Theo M. de Kok2, Michelle Plusquin1 and Tim S. Nawrot1,3* 1Center for Environmental Sciences, Hasselt University, Hasselt, Belgium 2Department of Toxicogenomics, Maastricht University, Maastricht, Netherlands 3Department of Public Health, Environment and Health Unit, Leuven University (KU Leuven), Leuven, Belgium Maternal body mass index (BMI) before pregnancy is known to affect both fetal growth and later-life health of the newborn, yet the implicated molecular mechanisms remain largely unknown. As the master reg...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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