Primary lateral sclerosis and the amyotrophic lateral sclerosis –frontotemporal dementia spectrum

ConclusionThe cognitive profile in PLS resembles ALS –FTD, without prominent behavioural disturbances. A higher RMT in PLS than ALS and ALS–FTD is consistent with differential cortical motor neuronal abnormalities and more severe involvement of corticospinal axons while SICI, indicative of inhibitory interneuronal dysfunction was comparable with A LS and ALS–FTD. Overall, while these findings support the notion that PLS lies on the ALS–FTD spectrum, the mechanisms underlying slow disease progression are likely to be distinct in PLS.

http://link.springer.com/10.1007/s00415-018-8917-5

Source: Journal of Neurology - June 4, 2018 Category: Neurology Source Type: research