A coherent roadmap to generate either pancreatic acinar or duct-like cells from human pluripotent stem cells challenges pancreatic cancer biology

Objectives Cell bioengineering approaches not only hold great promise to replace and regenerate dysfunctional tissue for improved life quality of the diseased patient but may also provide more sophisticated disease models. Engineering approaches to build human pancreatic tissue resembling acinar, ductal and endocrine tissue have been hampered by the complexity of the pancreas. Human pluripotent stem cells (PSCs) may provide the appropriate bioengineering platform for developmental and biomedical studies due to their capability to differentiate into every cell type in the human body.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 4. Experimental pancreatitis and cell biology II Source Type: research