Lipopeptide Paenipeptin Analogues Potentiate Clarithromycin and Rifampicin against Carbapenem-Resistant Pathogens.

Lipopeptide Paenipeptin Analogues Potentiate Clarithromycin and Rifampicin against Carbapenem-Resistant Pathogens. Antimicrob Agents Chemother. 2018 May 29;: Authors: Moon SH, Huang E Abstract Two paenipeptin analogues at 4 μg/ml potentiated clarithromycin and rifampicin against carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae strains. The combined treatment significantly increased their antibacterial efficacy in a microbiological medium and in human serum in vitro at therapeutically-relevant concentrations. Moreover, these two paenipeptins analogues showed low cytotoxicity against a human kidney cell line. Therefore, the combination therapy with paenipeptins may be an option for the treatment of antibiotic-resistant bacterial infections. PMID: 29844042 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research