Lipopeptide Paenipeptin Analogues Potentiate Clarithromycin and Rifampicin against Carbapenem-Resistant Pathogens.
Lipopeptide Paenipeptin Analogues Potentiate Clarithromycin and Rifampicin against Carbapenem-Resistant Pathogens.
Antimicrob Agents Chemother. 2018 May 29;:
Authors: Moon SH, Huang E
Abstract
Two paenipeptin analogues at 4 μg/ml potentiated clarithromycin and rifampicin against carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae strains. The combined treatment significantly increased their antibacterial efficacy in a microbiological medium and in human serum in vitro at therapeutically-relevant concentrations. Moreover, these two paenipeptins analogues showed low cytotoxicity against a human kidney cell line. Therefore, the combination therapy with paenipeptins may be an option for the treatment of antibiotic-resistant bacterial infections.
PMID: 29844042 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Moon SH, Huang E Tags: Antimicrob Agents Chemother Source Type: research
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