Real-world antidiabetic drug use and fracture risk in 12,277 patients with type 2 diabetes mellitus: a nested case –control study

ConclusionsInsulin monotherapy was associated with an increased fracture risk compared to MTF monotherapy in T2DM patients. Fracture risk should be taken into account when starting a glucose-lowering drug as part of T2DM treatment.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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Insulin impedes osteogenesis of BMSCs by inhibiting autophagy and promoting premature senescence via the TGF-β1 pathway. Aging (Albany NY). 2020 Feb 03;12: Authors: Zhang P, Zhang H, Lin J, Xiao T, Xu R, Fu Y, Zhang Y, Du Y, Cheng J, Jiang H Abstract The dysfunction of bone marrow stromal cells (BMSCs) may be a core factor in Type 2 diabetes mellitus (T2DM) associated osteoporosis. However, the underlying mechanism is not well understood. Here, we delineated the critical role of insulin impeding osteogenesis of BMSCs in T2DM. Compared with BMSCs from healthy people (H-BMSCs), BMSCs from T2DM pati...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
As primary care physicians, advance practice providers, or other members of the health care team, we recommend physical activity to most if not all patients we see. On a population basis, and most importantly, regular physical activity prevents the development of coronary artery disease and reduces symptoms in patients with established cardiovascular disease. Furthermore, evidence supports the role of exercise in reducing the risk of several other chronic diseases, including type 2 diabetes mellitus, osteoporosis, obesity, and cancer of the breast and colon.
Source: Primary Care: Clinics in Office Practice - Category: Primary Care Authors: Tags: Preface Source Type: research
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
In this study, we found tubeimoside I, a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae), significantly ameliorated the decrease of bone mass in type 2 diabetes-induced osteoporosis in rats. It appears that tubeimoside I exerts this protecting effect through inhibiting osteoclast formation and function. Futhermore, our study showed that tubeimoside I inhibits NF-κB transcriptional activation and degradation of IκBα. Collectively, our results reveal that tubeimoside I attenuates osteoclastogenesis through down-regulating NF-κB signali...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
In this study, the relationship among the Geriatric Nutritional Risk Index (GNRI), bone mineral density (BMD) and osteoporosis in type  2 diabetes mellitus patients was explored, and the GNRI predictive value was evaluated.Materials and MethodsWe enrolled 225 men and 192 women with type  2 diabetes mellitus. Their general condition, and laboratory and BMD data were collected. Spearman’s partial correlation analysis adjusting for age, body mass index and albumin was used for exploring the association among the GNRI, BMD and bone metabolism markers. Statistical analyses, including multivariate regression anal...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
ConclusionThe prevalence of osteoporosis and osteopenia in patients with T2DM is high. Female gender, increasing age, normal BMI, low serum 25-hydroxyvitamin D, and pioglitazone use further increase the risk of osteoporosis.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
AbstractIntroductionLow body weight and hypoalbuminemia were independently associated with osteoporosis, the relationship among Geriatric Nutritional Risk Index (GNRI), Bone Mineral Density (BMD) and osteoporosis in Type 2 Diabetes Mellitus (T2DM) was explored and the GNRI predictive value was evaluated.Materials and MethodsWe enrolled 225 men and 192 women suffered from T2DM. Their general condition, laboratory, and BMD data were collected. Spearman ’s partial correlation analysis adjusting for age, BMI and albumin was used for exploring the association among GNRI, BMD and bone metabolism markers. Statistical analys...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractPurpose of ReviewIndividuals with type 1 and type 2 diabetes mellitus (T1DM, T2DM) have an increased risk of bone fracture compared to non-diabetic controls that is not explained by differences in BMD, BMI, or falls. Thus, bone tissue fracture resistance may be reduced in individuals with DM. The purpose of this review is to summarize work that analyzes the effects of T1DM and T2DM on bone tissue compositional and mechanical properties.Recent FindingsStudies of clinical T2DM specimens revealed increased mineralization and advanced glycation endproduct (AGE) concentrations and significant relationships between mecha...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Authors: Giovos G, Yavropoulou MP, Yovos JG Abstract The improving effectiveness of health care leads inevitably to a rapid increase in the elderly population worldwide. At advanced ages, however, people experience chronic disabilities, which significantly increase the social and economic burden while curtailing survival, independence, and quality of life of the aging population. As aging is a multifactorial process, apart from genetic predisposition, other environmental factors, such as chronic sterile inflammation and cellular senescence, contribute as crucial participants and have been targeted to reverse their ...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
In conclusion, Dapagliflozin can prevent osteoporosis in ZDF rats by alleviating hypercalciuria.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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