Hyperglycemia Affects the Expression of Inflammatory Genes in Peripheral Blood Mononuclear Cells of Patients with Type 2 Diabetes.

CONCLUSION: The observed changes in both IL-1β and IL-6 mRNA levels in PBMCs may contribute to the development of inflammatory processes involved in the pathogenesis of T2D. Downregulation of IL1R1 in individuals with mild hyperglycemia may indicate an attempt to reduce the pro-inflammatory effects of IL-1β via auto-stimulation. PMID: 29851525 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29851525?dopt=Abstract

Source: Immunological Investigations - June 2, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research