Pre-specification of statistical analysis approaches in published clinical trial protocols was inadequate

Results from randomized trials can depend upon the statistical analysis approach used. It is important to pre-specify the analysis approach in the trial protocol to avoid selective reporting of analyses based on which provides the most favourable results. We undertook a review of published trial protocols to assess how often the statistical analysis of the primary outcome was adequately pre-specified.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Source Type: research