The associations between the changes in serum inflammatory markers and bone mineral accrual in boys with overweight and obesity during pubertal maturation: a 3-year longitudinal study in Estonian boys

AbstractSummaryAdipose tissue produces different inflammatory cytokines which compromise bone mineral accrual during puberty. Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), interleukin (IL)-8, and interferon-gamma (IFN- γ) are significantly related to bone mineral accrual during pubertal maturation in boys with different BMI values.IntroductionThis longitudinal study aims to identify the inflammatory markers that most strongly associate with pubertal bone mineral density (BMD) increment in boys with overweight and obesity (OWB).MethodsTwenty-six OWB and 29 normal-weight boys were followed yearly for 3  years to measure changes in 12 serum inflammatory markers, BMD (by DXA), and apparent volumetric BMD. The OWB group was further divided into two subgroups according to their BMI gain during the 3-year period. Data through time points presented as slopes were used to calculate correlation coefficie nts to explore the possible relationships between variables of interest. In the whole study group, linear mixed effects (LME) models were also used.ResultsIncrement in serum VEGF concentration was inversely associated with an increase in total body (TB) BMD (r = − 0.82,P = 0.02) and TB bone mineral content (BMC)/height (r = − 0.82,P = 0.02) in those OWB whose BMI gain was higher during pubertal years. In the whole study group, the LME model confirmed the inverse asso...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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Often we don’t really consider gender dynamics in treatment or medication. A lot of medications are only tested on men because of the risk of pregnancy, etc. This means there are whole drugs that have made it to market that may not have ever been tested with women. Schizophrenia affects women in many different ways than men. In this episode schizophrenic Rachel Star Withers and cohost Gabe Howard discuss differences in age, symptoms, treatments, lifestyle, parenthood in the genders as they experience schizophrenia. Dr. Hayden Finch joins to explain the medical side.  Highlights in “Schizophrenia in Women...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Mental Health and Wellness Women's Issues Gender Differences Mental Disorder Mental Illness Psychiatry Psychology Psychotherapy Women's Health women's mental health Source Type: blogs
Abstract Physicians often overlook exercise as a treatment or prophylactic measure for many common diseases and ailments. It can be used to treat comorbidities including obesity, cardiovascular disease, chronic obstructive pulmonary disease, diabetes mellitus, osteoporosis, osteoarthritis, cancer, and low back pain. Education on the general physical activity guidelines as well as easy exercise prescription methods can improve the ability of physicians to prescribe exercise as a therapeutic option. In addition, identifying barriers to compliance with exercise and ways to overcome these barriers is also necessary in...
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Med Clin North Am Source Type: research
Background: Osteoporosis and obesity are two major public health problems worldwide. Considering the conflicting results about the association between anthropometric measurement and bone mineral density (BMD) and also differences between various races, this study was designed to examine the relationship between anthropometric measurements and BMD in a sample of Iranian adults.Methods: This cross ‑sectional population‑based study was conducted on 2625 Iranian adults aged 18 and above who were selected using multistage, cluster sampling method from Sanandaj and Arak (two cities of Iran). The evaluated variables included ...
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Prior to bariatric surgery, endocrine causes of obesity must be excluded. The diagnosis of osteoporosis in a male requires the study of secondary causes of this condition. The diagnostic delay of Cushing's syndrome may have irreversible consequences. AbstractPrior to bariatric surgery, endocrine causes of obesity must be excluded. The diagnosis of osteoporosis in a male requires the study of secondary causes of this condition. The diagnostic delay of Cushing's syndrome may have irreversible consequences.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
Conditions:   Osteoporosis Senile;   Obesity, Visceral Interventions:   Diagnostic Test: Body mass index;   Diagnostic Test: waist circumference;   Diagnostic Test: hip circumference;   Diagnostic Test: height;   Diagnostic Test: Fat percentage;   Diagnostic Test: Skeletal muscle index;   Diagnostic Test: A body shape index (ABSI);   Diagnostic Test: Dual energy x ray absorptiometry (DXA);   Diagnostic Test: The Rapid Assessment of Phys...
Source: - Category: Research Source Type: clinical trials
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
As primary care physicians, advance practice providers, or other members of the health care team, we recommend physical activity to most if not all patients we see. On a population basis, and most importantly, regular physical activity prevents the development of coronary artery disease and reduces symptoms in patients with established cardiovascular disease. Furthermore, evidence supports the role of exercise in reducing the risk of several other chronic diseases, including type 2 diabetes mellitus, osteoporosis, obesity, and cancer of the breast and colon.
Source: Primary Care: Clinics in Office Practice - Category: Primary Care Authors: Tags: Preface Source Type: research
Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
Source: Epigenetics - Category: Genetics & Stem Cells Authors: Source Type: research
Comorbidity is the presence of one or more additional conditions co-occurring with a primary condition. In this episode, host schizophrenic Rachel Star Withers with her cohost Gabe Howard will be discussing comorbidity with schizophrenia. Comorbidity is associated with worse health outcomes, more complex clinical management and increased health care costs. Occupational therapist and host of the podcast Occupied, Brock Cook, will be joining us to discuss ways that he works with people with schizophrenia to manage multiple health issues.  Highlights from “Comorbidity with Schizophrenia” Episode [01:28] What ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Psychotherapy Bipolar disorder and schizophrenia comorbid comorbid psychiatric conditions Comorbidities Comorbidity Diagnosis Of Schizophrenia Livi Source Type: blogs
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