Acquired Aplastic Anemia: What Have We Learned and What Is in the Horizon?

Acquired Aplastic Anemia: What Have We Learned and What Is in the Horizon? Pediatr Clin North Am. 2018 Jun;65(3):597-606 Authors: Savaşan S Abstract Acquired aplastic anemia (aAA) characterized by peripheral pancytopenia and bone marrow aplasia is a rare and serious disorder. Differential diagnosis includes constitutional bone marrow failure syndromes and myelodysplastic disorders. Autoimmune reaction to altered hematopoietic stem cells highlights the underlying mechanism. Matched related donor allogeneic hematopoietic stem cell transplantation is the ideal pediatric treatment; alternative approaches include immunosuppressive therapy and use of eltrombopag. Progression to clonal disorders can occur. Recently, alternative donor hematopoietic stem cell transplantation outcomes have significantly improved. Despite advances, aAA continues to be a challenge for hematologists. PMID: 29803285 [PubMed - in process]
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Pediatr Clin North Am Source Type: research