Tuberculosis and Sarcoidosis Imaging in 18F-FDG-PET/CT: Consistencies and Inconsistencies

Conclusions: Apart from the common capability of showing anatomic spread of disease in the whole body in one single examination for both TB and SC, in TB 18F-FDG seems to be a good predictor for the extent of disease by assessment of the highest SUV seen in any pathological lesion and for therapy control, too, as indicated in earlier work. In SC, FDG-uptake markedly focuses on lymph nodes, consistent with the natural history of the disease. However, we see uptake behavior clearly different from TB in respect of the prediction of disease extent and some other features. Evaluation of the relevance of these facts for initial diagnosis and therapy control in SC is under way.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research

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We present here preliminary descriptive data on the patients' characteristics and their established diagnosis at follow-up.Methods: Since 2015, all patients aged ≥15 years and referred to the hematology or internal medicine department in 117 French hospitals, with an unexplained SM diagnosis (confirmed by echography or CT-scan with a craniocaudal length ≥13 cm) have been invited to participate. Unexplained cause of SM was defined as a first negative clinical workup based on patient's interview and physical examination, and biological routine tests (including complete blood and reticulocytes count, clotting test, live...
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster III Source Type: research
CONCLUSIONS: FDG-PET scan can be used as an important adjunct non-invasive investigation in diagnosing and monitoring of various benign lung conditions. It also helps in assessing whole body disease burden which may change therapeutic decisions. PMID: 30152649 [PubMed - in process]
Source: Indian Journal of Chest Diseases and Allied Sciences - Category: Respiratory Medicine Tags: Indian J Chest Dis Allied Sci Source Type: research
Ashu S Bhalla, A Das, P Naranje, A Goyal, R Guleria, Gopi C KhilnaniIndian Journal of Radiology and Imaging 2017 27(4):380-388 The second part of the review discusses the role of different existing imaging modalities in the evaluation of thoracic sarcoidosis, including chest radiograph, computed tomography, magnetic resonance imaging, endobronchial ultrasound, and positron emission tomography. While summarizing the advantages and pitfalls of each imaging modality, the authors propose imaging recommendations and an algorithm to be followed in the evaluation of clinically suspected case of sarcoidosis in tuberculosis-endemic regions.
Source: Indian Journal of Radiology and Imaging - Category: Radiology Authors: Source Type: research
Introduction: Errors in diagnosis of pulmonary granulomatoses reach 75%. Treatment effectiveness depends on timely diagnosis, course and activity of the disease.Aim: To perform differential diagnosis of disseminated pulmonary TB (DPT), hypersensitivity pneumonitis (HP), pulmonary sarcoidosis (PS) and pulmonary non-tuberculous mycobacterioses (NTM) by MSCT and SPECT scanning with 99m Tc-technetril.Methods: The analysis of MSCT and SPECT with 99m Tc-technetril data on 130 cases: DPT – 40; PS, HP and NTM – 30 in each group. We used the Siemens MSCT scanner "Somatom Emotion 16"; the gamma camera "Nuc...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
We report a case of a 52-year-old female with irritable cough. CT showed a lung mass with multiple bilateral lung nodules, and sarcoidosis was suspected. F-18 FDG PET/CT was undertaken for the diagnosis and showed intense uptake of FDG in the mass in the lower lobe of the right lung, multiple lymph nodes, liver, and spleen. The maximum standardized uptake value of F-18 FDG was 43.58. This pattern of involvement most likely represents lymphomatous involvement. Diagnoses: Histopathology suggested tubercular involvement. Intervention and outcomes: The patient received anti-TB treatment and recovered. Lessons: Abovementione...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion: For evaluation of indeterminate lymphadenopathy in this population, FDG PET/CT had very poor PPV (i.e., frequent false positive results with benign / inflammatory etiologies, as would be expected) but had very high NPV of 97%. Such strong NPV renders malignancy very unlikely in cases where FDG PET is negative (representing 33% of patients in this cohort), which may allow for more confident observation of FDG-negative cases thus potentially avoiding costly and invasive procedures such as EBUS, mediastinoscopy or CT-guided biopsies, especially in elderly patients. Research Support: N/A
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lymphoma - Adult Source Type: research
Authors: Li CR, Li YZ, Li YM, Zheng YS Abstract OBJECTIVE: Our main aim was to investigate the effect of dynamic and contrast enhanced CT imaging on differential diagnosis of lung carcinoma, pulmonary tuberculoma, inflammatory pseudotumor, and coexisting pulmonary tuberculosis and lung cancer. PATIENTS AND METHODS: About, 144 patients with pulmonary sarcoidosis as the study subjects were chosen which included: 36 patients with lung carcinoma, 36 patients with pulmonary tuberculoma, 36 patients with inflammatory pseudotumor, 36 patients with coexisting pulmonary tuberculosis and lung cancer. CT imaging scan was ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Conclusion Identification of factors associated with abnormal investigations might improve the optimal diagnostic workup adapted to each patient.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conclusion: Tuberculosis remains most common cause of bronchiectasis at our centre (87.5%). However other important causes should always be ruled out. Mycobacteria Culture and CBNAAT tests both must be performed to rule out reactivation of tuberculosis and NTM detection.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 10.1 Respiratory Infections Source Type: research
l CP Abstract CLINICAL/METHODICAL ISSUE: Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. STANDARD RADIOLOGICAL METHODS: The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role. METHODICAL INNOVATIONS: Further radiological modalities are usually not needed in the routine work-...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
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