Tuberculosis and Sarcoidosis Imaging in 18F-FDG-PET/CT: Consistencies and Inconsistencies

Conclusions: Apart from the common capability of showing anatomic spread of disease in the whole body in one single examination for both TB and SC, in TB 18F-FDG seems to be a good predictor for the extent of disease by assessment of the highest SUV seen in any pathological lesion and for therapy control, too, as indicated in earlier work. In SC, FDG-uptake markedly focuses on lymph nodes, consistent with the natural history of the disease. However, we see uptake behavior clearly different from TB in respect of the prediction of disease extent and some other features. Evaluation of the relevance of these facts for initial diagnosis and therapy control in SC is under way.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research

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Ashu S Bhalla, A Das, P Naranje, A Goyal, R Guleria, Gopi C KhilnaniIndian Journal of Radiology and Imaging 2017 27(4):380-388 The second part of the review discusses the role of different existing imaging modalities in the evaluation of thoracic sarcoidosis, including chest radiograph, computed tomography, magnetic resonance imaging, endobronchial ultrasound, and positron emission tomography. While summarizing the advantages and pitfalls of each imaging modality, the authors propose imaging recommendations and an algorithm to be followed in the evaluation of clinically suspected case of sarcoidosis in tuberculosis-endemic regions.
Source: Indian Journal of Radiology and Imaging - Category: Radiology Authors: Source Type: research
Introduction: Errors in diagnosis of pulmonary granulomatoses reach 75%. Treatment effectiveness depends on timely diagnosis, course and activity of the disease.Aim: To perform differential diagnosis of disseminated pulmonary TB (DPT), hypersensitivity pneumonitis (HP), pulmonary sarcoidosis (PS) and pulmonary non-tuberculous mycobacterioses (NTM) by MSCT and SPECT scanning with 99m Tc-technetril.Methods: The analysis of MSCT and SPECT with 99m Tc-technetril data on 130 cases: DPT – 40; PS, HP and NTM – 30 in each group. We used the Siemens MSCT scanner "Somatom Emotion 16"; the gamma camera "Nuc...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
We report a case of a 52-year-old female with irritable cough. CT showed a lung mass with multiple bilateral lung nodules, and sarcoidosis was suspected. F-18 FDG PET/CT was undertaken for the diagnosis and showed intense uptake of FDG in the mass in the lower lobe of the right lung, multiple lymph nodes, liver, and spleen. The maximum standardized uptake value of F-18 FDG was 43.58. This pattern of involvement most likely represents lymphomatous involvement. Diagnoses: Histopathology suggested tubercular involvement. Intervention and outcomes: The patient received anti-TB treatment and recovered. Lessons: Abovementione...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion: For evaluation of indeterminate lymphadenopathy in this population, FDG PET/CT had very poor PPV (i.e., frequent false positive results with benign / inflammatory etiologies, as would be expected) but had very high NPV of 97%. Such strong NPV renders malignancy very unlikely in cases where FDG PET is negative (representing 33% of patients in this cohort), which may allow for more confident observation of FDG-negative cases thus potentially avoiding costly and invasive procedures such as EBUS, mediastinoscopy or CT-guided biopsies, especially in elderly patients. Research Support: N/A
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lymphoma - Adult Source Type: research
Authors: Li CR, Li YZ, Li YM, Zheng YS Abstract OBJECTIVE: Our main aim was to investigate the effect of dynamic and contrast enhanced CT imaging on differential diagnosis of lung carcinoma, pulmonary tuberculoma, inflammatory pseudotumor, and coexisting pulmonary tuberculosis and lung cancer. PATIENTS AND METHODS: About, 144 patients with pulmonary sarcoidosis as the study subjects were chosen which included: 36 patients with lung carcinoma, 36 patients with pulmonary tuberculoma, 36 patients with inflammatory pseudotumor, 36 patients with coexisting pulmonary tuberculosis and lung cancer. CT imaging scan was ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Conclusion Identification of factors associated with abnormal investigations might improve the optimal diagnostic workup adapted to each patient.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conclusion: Tuberculosis remains most common cause of bronchiectasis at our centre (87.5%). However other important causes should always be ruled out. Mycobacteria Culture and CBNAAT tests both must be performed to rule out reactivation of tuberculosis and NTM detection.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 10.1 Respiratory Infections Source Type: research
l CP Abstract CLINICAL/METHODICAL ISSUE: Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. STANDARD RADIOLOGICAL METHODS: The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role. METHODICAL INNOVATIONS: Further radiological modalities are usually not needed in the routine work-...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Abstract OBJECTIVE: Presentation of the etiology, pathology, clinical course, radiology and differential diagnostics of skeletal sarcoidosis. PATHOANATOMICAL PRINCIPLES: Noncaseating epithelioid cell granulomas can trigger solitary, multiple or disseminated osteolysis, reactive osteosclerosis and/or granulomatous synovitis. INCIDENCE: The incidence of sarcoidosis is 10-12 per 100,000 inhabitants per year. Skeletal involvement is approximately 14 %. CLINICAL ASPECTS: Skeletal involvement occurs almost exclusively in the stage of lymph node and pulmonary manifestation. Most cases of skeletal in...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
DISCUSSION: A CT should be considered in the presence of giant-cell granulomas, even in the absence of caseous necrosis, and where both direct examination and culture for the skin are negative. Our case also underlines the importance of an extensive workup to rule out disseminated disease even if the patient is not symptomatic. PMID: 27342431 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
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