Novel approach of FDG PET for diagnosing of cardiac sarcoidosis -application possibility of the texture analysis-

1512Objectives: FDG PET plays a significant role in the diagnosis of cardiac sarcoidosis (CS). Texture analysis is a group of computational methods extracting information about the relationship between adjacent pixels or voxels and evaluates the inhomogeneity. We attempted to evaluate whether texture analysis reflecting myocardial FDG uptake has additional value in the diagnosis of CS. Methods: All CS patients fasted for at least 18 hours. Non-CS patients were instructed not to consume any food other than plain water for at least 6 hours prior to the time of injection of FDG. Approximately 4.5 MBq/ kg (body weight) of FDG were administered intravenously. CS patient was positioned supine in the PET/CT scanner at sixty minutes (1st scan; 3 minutes/bed for whole-body imaging) and 75 minutes (2nd scan; 5 minutes/bed for thoracic region) after tracer injection to assess the inter-scan reproducibility. At first, inter-operator and inter-scan reproducibility of the FDG uptake parameters including SUVmax and texture parameters were evaluated in the CS patients. The threshold of the significant accumulation was defined as 1.5 x SUVmean of blood pool (ref 1). Polar map, which was divided into 256 x 256 segment regions and uptake was resampled into 64 degrees from the lowest to the highest SUV, were applied for the texture analysis described by Orlhac et al (total of 36 parameters) (ref 2). We developed ‘ptexture’ open-source package of Python3 to compute texture features of...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Basic Science Poster Session Source Type: research

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CONCLUSION: EBUS-TBNA is associated with a risk of mediastinitis that may manifest as an isolated fever arising within hours of the procedure. The pathogens responsible are usually contaminants from the oropharynx such as Streptococcus sp, probably inoculated directly into the mediastinum during transbronchial needle aspiration. Rapid diagnosis and treatment are necessary in order to reduce morbidity and mortality associated with mediastinitis. PMID: 30098879 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
ConclusionsVariation in measures used, dietary prescriptions, fasting times, species and study quality makes result comparison and applicability difficult. Definitive dietary recommendations are not possible based on current evidence.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
ConclusionNecrotising retinopathy-like lesions mimicking an infectious process or a lymphoproliferative disorder can be an atypical manifestation of ocular sarcoidosis.
Source: Journal of Ophthalmic Inflammation and Infection - Category: Opthalmology Source Type: research
Introduction We evaluated the role of gallium-68-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-octreotide (68Ga-DOTA-NOC) PET/CT in assessing sarcoidosis disease activity. Patients and methods Patients diagnosed with sarcoidosis underwent 68Ga-DOTA-NOC-PET/CT. The maximum standardized uptake value (SUVmax) at the pathological site and in the descending thoracic aorta (reference standard, SUVmed) were assessed. A SUVmax/SUVmed ratio (disease activity score) of more than one was considered a marker of active disease and was compared with the clinical symptoms and serum angiotensin-converting ...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Conclusion18F-FDG PET/CT can be a useful tool for scanning the whole body to suggest the FUO cause.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Publication date: April–June 2018Source: Saudi Journal of Ophthalmology, Volume 32, Issue 2Author(s): Daniele Cirone, Luca Cimino, Giovanni SpinucciAbstractSarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging.We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations.A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous...
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
Publication date: April 2018Source: Cor et Vasa, Volume 60, Issue 2Author(s): Petr Kopriva, Martin Griva, Zbynek TüdösAbstractSarcoidosis is a multi-system granulomatous disorder of unclear etiology which can affect any organ of the body including the heart. The heart is involved in up to 25% of sarcoidosis patients. In rare cases, the heart can be the only organ involved.Involvement of the heart, called cardiac sarcoidosis, especially if symptomatic, significantly deteriorates the prognosis for sarcoidosis patients, which is why cardiac sarcoidosis should be not only considered, but also searched for actively. D...
Source: Cor et Vasa - Category: Cardiology Source Type: research
ConclusionLeft ventricle MC is very rare. The dystrophic MC from ischemic origin is the most frequent. At long-term follow-up, 59% of MC had altered LVEF, it is more frequent (80%) in I-MC. The extent of LV MC was associated with high risk of cardiac death and ventricular arrhythmia.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
SUMMARY: Involvement of the central nervous system by sarcoidosis, also referred to as neurosarcoidosis, is seen clinically in about 5% of patients with systemic disease. CNS involvement most frequently affects the leptomeninges and cranial nerves, though the ventricular system, brain parenchyma, and pachymeninges may also be involved. Even though the involvement of the intracranial vascular structures is well-known on postmortem studies, there is scant literature on imaging manifestations secondary to the vessel wall involvement, being confined mostly to isolated case reports and small series. The authors present a review...
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
Publication date: April–June 2018Source: Saudi Journal of Ophthalmology, Volume 32, Issue 2Author(s): Daniele Cirone, Luca Cimino, Giovanni SpinucciAbstractSarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging.We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations.A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous...
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
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