Novel approach of FDG PET for diagnosing of cardiac sarcoidosis -application possibility of the texture analysis-

1512Objectives: FDG PET plays a significant role in the diagnosis of cardiac sarcoidosis (CS). Texture analysis is a group of computational methods extracting information about the relationship between adjacent pixels or voxels and evaluates the inhomogeneity. We attempted to evaluate whether texture analysis reflecting myocardial FDG uptake has additional value in the diagnosis of CS. Methods: All CS patients fasted for at least 18 hours. Non-CS patients were instructed not to consume any food other than plain water for at least 6 hours prior to the time of injection of FDG. Approximately 4.5 MBq/ kg (body weight) of FDG were administered intravenously. CS patient was positioned supine in the PET/CT scanner at sixty minutes (1st scan; 3 minutes/bed for whole-body imaging) and 75 minutes (2nd scan; 5 minutes/bed for thoracic region) after tracer injection to assess the inter-scan reproducibility. At first, inter-operator and inter-scan reproducibility of the FDG uptake parameters including SUVmax and texture parameters were evaluated in the CS patients. The threshold of the significant accumulation was defined as 1.5 x SUVmean of blood pool (ref 1). Polar map, which was divided into 256 x 256 segment regions and uptake was resampled into 64 degrees from the lowest to the highest SUV, were applied for the texture analysis described by Orlhac et al (total of 36 parameters) (ref 2). We developed ‘ptexture’ open-source package of Python3 to compute texture features of...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Basic Science Poster Session Source Type: research

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AbstractPurpose of ReviewThe purpose of this paper is to provide an updated review of recent advances in protocols for positron emission tomography (PET) or PET/computed tomography (PET/CT) imaging in patients with sarcoidosis.Recent FindingsThere has been more research focused on developing newer and improved PET imaging modalities to diagnose and follow-up cardiac sarcoidosis (CS). Fluorine-18-fluorodeoxyglucose (18F- FDG)-PET are widely used to diagnose CS, with or without concurrent rest nuclear myocardial perfusion study. There have been various patient preparation strategies for FDG PET/CT in CS. Interpretation crite...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research
Authors: Yada H, Soejima K Abstract Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. The annual incidence of systemic sarcoidosis is estimated at 10-20 per 100,000 individuals. Owing to the recent advances in imaging modalities, cardiac sarcoidosis (CS) is diagnosed more frequently. The triad of CS includes conduction abnormality, ventricular tachycardia, and heart failure. Atrial and ventricular arrhythmias are caused by either inflammation or scar formation. Inflammation should be treated with immunosuppression and antiarrhythmic agents and scar formation should be treated with antiarrhyth...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
CONCLUSION: 18F-FDG PET/CT enabled the diagnosis of intraocular sarcoidosis even in patients with a normal CT scan. Older age at diagnosis, presence of synechiae and elevated ACE are associated with positive findings on 18F-FDG PET/CT consistent with sarcoidosis. PMID: 30658987 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
An 80-year-old man with metastatic melanoma had been receiving treatment with pembrolizumab from September 2015 until June 2017. Series FDG PET/CT scans from March 7, 2017, to June 14, 2018, showed the course of biopsy-proven pembrolizumab-induced sarcoidosis. Reported here is the first case of multiorgan sarcoidosis induced by pembrolizumab and its self-resolving course on FDG PET/CT.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
ConclusionThe current meta-analysis showed the moderate sensitivity and specificity of F-18 FDG PET or PET/CT for diagnosis of CS. The presence of combined myocardial perfusion imaging could improve diagnostic accuracy of F-18 FDG PET or PET/CT for diagnosis of CS. At present, the literature regarding the use of F-18 FDG PET for detection of CS remains limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of F-18 FDG PET for diagnosis of CS.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
This article reviews how the SSTR-directed theranostic concept is currently applied and also reflects on recent developments that hold promise for the future of theranostics in this context.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Rationale: Sarcoidosis is a multisystem disorder characterized by noncaseating granulomas. The nervous system is involved in 5 to 16% of the patients. However, neurosarcoidosis in the medulla oblongata presenting as hiccough is remarkably rare. Patient concern: A 55-year-old female was admitted to our hospital suffering from intractable hiccough and progressive numbness of extremities. Diagnosis: The MR imaging revealed a circumscribed mass lesion located on the medulla oblongata. The mass was hyperintense on T2-weighted images and enhanced homogeneously with gadolinium-diethylenetriamine penta-acetic acid. The cer...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In conclusion, using newer sensitive imaging tool we detected 36 (9.2%) patients with serious pathologies before the first symptoms. Therefore we believe, that ¹F-FDG PET/CT imaging can be recommended to be done not only in all MGUS patients with suspected SMM or active MM, but also for early identification of other serious pathologies.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster I Source Type: research
We present here preliminary descriptive data on the patients' characteristics and their established diagnosis at follow-up.Methods: Since 2015, all patients aged ≥15 years and referred to the hematology or internal medicine department in 117 French hospitals, with an unexplained SM diagnosis (confirmed by echography or CT-scan with a craniocaudal length ≥13 cm) have been invited to participate. Unexplained cause of SM was defined as a first negative clinical workup based on patient's interview and physical examination, and biological routine tests (including complete blood and reticulocytes count, clotting test, live...
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster III Source Type: research
Sarcoidosis is a progressive multisystem disease which is primarily affecting the lungs and is characterized by epithelioid granulomas in various organs and tissues. It is suggested that the severity of sarcoidosis is determined by a violation of endithelial function.Aim: To determine the features of VEGF production during the active course of lung sarcoidosis.Materials and Methods: Twenty three patients with lung sarcoidosis were examined. The VEGF level was determined using ELISA (enzyme-linked immunosorbent assay) and test of R&D systems Kuantykine (USA). Comparisons were made with the morphological data and the results...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
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