Novel approach of FDG PET for diagnosing of cardiac sarcoidosis -application possibility of the texture analysis-

1512Objectives: FDG PET plays a significant role in the diagnosis of cardiac sarcoidosis (CS). Texture analysis is a group of computational methods extracting information about the relationship between adjacent pixels or voxels and evaluates the inhomogeneity. We attempted to evaluate whether texture analysis reflecting myocardial FDG uptake has additional value in the diagnosis of CS. Methods: All CS patients fasted for at least 18 hours. Non-CS patients were instructed not to consume any food other than plain water for at least 6 hours prior to the time of injection of FDG. Approximately 4.5 MBq/ kg (body weight) of FDG were administered intravenously. CS patient was positioned supine in the PET/CT scanner at sixty minutes (1st scan; 3 minutes/bed for whole-body imaging) and 75 minutes (2nd scan; 5 minutes/bed for thoracic region) after tracer injection to assess the inter-scan reproducibility. At first, inter-operator and inter-scan reproducibility of the FDG uptake parameters including SUVmax and texture parameters were evaluated in the CS patients. The threshold of the significant accumulation was defined as 1.5 x SUVmean of blood pool (ref 1). Polar map, which was divided into 256 x 256 segment regions and uptake was resampled into 64 degrees from the lowest to the highest SUV, were applied for the texture analysis described by Orlhac et al (total of 36 parameters) (ref 2). We developed ‘ptexture’ open-source package of Python3 to compute texture features of...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Basic Science Poster Session Source Type: research

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Condition:   Cardiac Sarcoidosis Interventions:   Drug: 68Ga-DOTATATE PET/CT;   Drug: 18FDG PET/CT scan;   Drug: 13NH3 PET/CT scan Sponsor:   Mayo Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Even though NF1 patients did not show an increased risk of thyroid incidentaloma on PET/CT compared to previous studies on non-thyroid cancer patients, the incidence shows that awareness of possible thyroid disease is important.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
Abstract The recent association between the increase in the number of neonates with microcephaly in northeastern Brazil and the outbreak of infection with the Zika virus, which has been occurring in the Americas, has been declared a public health emergency of international concern. The evidence that implicates the virus as the cause of this public health emergency has been demonstrated ever more consistently. This pictorial essay illustrates the imaging characteristics seen on computed tomography and magnetic resonance imaging scans of infants admitted to a rehabilitation hospital with a diagnosis of microcephaly and a mat...
Source: Radiologia Brasileira - Category: Radiology Source Type: research
Conclusion: These metrics can prove to be a useful part of the visual criteria for satisfactory quality assurance in cardiac FDG PET imaging for the purposes of sarcoidosis assessment.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
Conclusion 18F-FDG PET-CT is an effective tool in the clinical management of CS, including its initial diagnosis and assessment following therapy. Although not statistically significant, patients treated for a longer duration were more likely to respond to the therapy. Additionally, dual immunomodulator therapy with prednisone and methotrexate may improve therapeutic response in CS. Figure 1. F-18 FDG PET-CT MIP and axial fused PET-CT images showing (A) focal on diffuse hypermetabolic activity in the left ventricular myocardium consistent with cardiac sarcoidosis, and (B) resolution of the myocardial activity following imm...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research
1542Objectives: Cardiac sarcoidosis (CS) is rare but a potentially life-threatening disease that causes conduction disturbance, systolic dysfunction, and most notably sudden cardiac death. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) plays important roles not only in the diagnosis of CS but also in the evaluation of therapeutic effects of anti-inflammatory therapy. A volume-based analysis by FDG PET including cardiac metabolic volume (CMV) has emerged as a new assessment tool for measuring the volume within the boundary determined by reference tissue such as the liver and the blood...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research
1575Background: Sarcoidosis is a multisystem disease of unknown etiology. The prevalence of clinically evident cardiac involvement is about 5%, though this may be an underestimation given the difficulties of diagnosing cardiac sarcoidosis (CS). Only 40% of patients with CS diagnosed at autopsy have the diagnosis made during their lifetime. Cardiac PET is an excellent tool for diagnosis and follow up of CS patients. Little is known of the regional myocardial involvement of CS. In the current series, we utilize PET to determine the most commonly sarcoid-afflicted myocardium regions. Methods: 45 patients (mean age 54 +/- 8.4,...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research
Conclusions: The classification performance of DCNN-based features outperformed the CoV-based classification performance. Experimental results suggested that DCNN-based high-dimensional features have a potential of semi-automated diagnosis of CS.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Deep Learning In Molecular Imaging Studies Source Type: research
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