Diuretic 68Ga-PSMA PET/CT : Evaluation of a Novel technique in Prostate Carcinoma

1458Objectives: Physiological renal excretion of 68Ga labelled PSMA may complicate the assessment of pelvic region in prostate carcinoma, with prostatic lesion being obscured by the high radio tracer bladder activity. Thereby can lead to problems in differentiating the pelvic lymph nodes from ureteral activity and challenges in local invasion of prostate carcinoma into the surrounding structures (seminal vesicles, urinary bladder and rectum.The aim of this retrospective study was to assess the utility of diuretic 68Ga-PSMA PET/CT imaging in the loco-regional staging of locally advanced prostate carcinoma. Materials and methods : Sixty one biopsy proven prostate cancer patients with mean age of 66.7 +/- 4.9 years who underwent 68Ga-PSMA PET/CT were evaluated after approval from the institutional ethics committee. All the patients underwent whole body 68 Ga-PSMA PET/CT scan followed by two bed position post-lasix PET/CT scan. The tracer activity in the prostate, bladder, seminal vesicle, lymph nodes and ureter were evaluated in pre-lasix and post-lasix images visually (scores 0,1,2 &3 were given for negative, equivocal, mildly positive and strongly positive ) and quantitatively by SUVmax of the tumour to background ratio( T:B ratio). Data was statistically analysed using Mann-Whitney U test and Paired t test and p value of
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate Posters Source Type: research

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