PET/CT-based radiation therapy for lung cancers: Pros and cons of proton vs. photon radiation therapy

1224Aim:Radeation therapy (RT) is an important component of cancer treatment for both early stage and locally advanced lung cancers. Photon and proton therapies are both utilized for RT but have different physical characteristics. Photon RT actively exposes healthy tissues along the beam path in front of and beyond the tumor to incidental irradiation. However, due to a central-axis depth-dose distribution pattern known as the spread-out Bragg peak (SOBP), proton RT generally has a more optimal dose delivery in comparison to 3D conformal photon therapy and intensity-modulated radiation therapy (IMRT). The SOBP may potentially allow for improvements in clinical outcomes in select cases by more safely and efficiently applying dose escalation/acceleration or RT with other treatment modalities like chemotherapy and surgery without increasing side effects such as radiation pneumonitis in lung cancer. Although proton RT is a promising technique on a clinical and scientific level, some challenges exist including target determination and motion effects. Proton doses are very sensitive to anatomical changes and motion effects, intrafractional tumor motion and normal tissue motion need to be taken into account for each patient, particularly in customized proton compensator design. Breathing causes lung and other thoracic normal tissues as well as cancer lesions to move during treatment. With the use of respiratory-gated 4D-positron emission tomography (PET) and 4D-computed tomography (C...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research

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In conclusion, the presence of anti-SOX1 abs alone is a potential predictor of an uncommon paraneoplastic neurological disorder, usually occurring in the setting of LEMS, PCD, and SCLC. The detection of anti-SOX1 abs contributes to an early diagnosis of underlying tumors, given the diversity of clinical symptoms and the absence of characteristic neuroimaging features. PMID: 33029958 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Publication date: Available online 9 October 2020Source: PhytomedicineAuthor(s): Jian-Shu Lou, Li-Ping Zhao, Zhi-Hui Huang, Xia-Yin Chen, Jing-Ting Xu, William Chi-Shing TAI, Karl W.K. Tsim, Yi-Tao Chen, Tian Xie
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 October 2020Source: Cancer CellAuthor(s): Melinda A. Pruis, Burhan Hussain, Marleen Bakker, Rogier A.S. Hoek, Jelle R. Miedema, Anne-Marie C. Dingemans, Marthe S. Paats
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Authors: Han AR, Lee S, Han S, Lee YJ, Kim JB, Seo EK, Jung CH Abstract Radiotherapy using ionizing radiation is a major therapeutic modality for advanced human lung cancers. However, ionizing radiation itself can induce malignant behaviors such as cancer cell migration and invasion, leading to local recurrence or distal metastasis. Therefore, safer and more effective agents that inhibit the metastatic behaviors of cancer cells in radiotherapy are needed. As a part of our ongoing search for new radiotherapy enhancers from medicinal herbs, we isolated the following triterpenoids from the ethanol extract of Centella ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 8 October 2020Source: European Journal of RadiologyAuthor(s): Tao Yu
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Chun-Pin Chang, Travis J. Meyers, Alan Fu, Ming-Yan Zhang, Donald P. Tashkin, Jian-Yu Rao, Wendy Cozen, Thomas M. Mack, Mia Hashibe, Hal Morgenstern, Zuo-Feng Zhang
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Abstract Intracavitary cardiac metastasis is a rare manifestation of primary lung cancer which can be associated with a very poor prognosis. In this condition, the right chambers of the heart are more commonly involved and the invasion of the left atrium (LA) through the venous routes is highly exceptional. Poorly differentiated large-cell neuroendocrine tumors also include only 3% of all primary lung carcinomas which can have adverse outcomes. Therefore, in this report, a rare case of a 72-year-old male patient with poorly differentiated large-cell neuroendocrine carcinoma of the right lung spreading to the LA th...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Ultrasound Source Type: research
Publication date: Available online 8 October 2020Source: The Annals of Thoracic SurgeryAuthor(s): Gail E. Darling, Martin C. Tammemägi, Heidi Schmidt, Daniel N. Buchanan, Yvonne Leung, Caitlin McGarry, Linda Rabeneck
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 8 October 2020Source: The Annals of Thoracic SurgeryAuthor(s): Jean-Baptiste Leclère, Ludovic Fournel, Harry Etienne, Charbel Al Zreibi, Ilaria Onorati, Arnaud Roussel, Yves Castier, Emmanuel Martinod, Françoise Le Pimpec-Barthes, Marco Alifano, Jalal Assouad, Pierre Mordant, thoracic surgery units of Paris Public Hospitals.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusion: This investigation provides a unique perspective into the biological growth of metastatic brain lesions. It is our hope that this study guides timing of treatment and informs both clinicians and patients of tumor growth kinetics before initiating treatment for intracranial metastases. PMID: 33024592 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
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