SUV-based analysis of Metabolic Priming of Myocardium for improved Diagnosis of Cardiac Sarcoidosis using 18F-FDG PET

Conclusion: These metrics can prove to be a useful part of the visual criteria for satisfactory quality assurance in cardiac FDG PET imaging for the purposes of sarcoidosis assessment.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research

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This article reviews how the SSTR-directed theranostic concept is currently applied and also reflects on recent developments that hold promise for the future of theranostics in this context.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
In conclusion, using newer sensitive imaging tool we detected 36 (9.2%) patients with serious pathologies before the first symptoms. Therefore we believe, that ¹F-FDG PET/CT imaging can be recommended to be done not only in all MGUS patients with suspected SMM or active MM, but also for early identification of other serious pathologies.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster I Source Type: research
We present here preliminary descriptive data on the patients' characteristics and their established diagnosis at follow-up.Methods: Since 2015, all patients aged ≥15 years and referred to the hematology or internal medicine department in 117 French hospitals, with an unexplained SM diagnosis (confirmed by echography or CT-scan with a craniocaudal length ≥13 cm) have been invited to participate. Unexplained cause of SM was defined as a first negative clinical workup based on patient's interview and physical examination, and biological routine tests (including complete blood and reticulocytes count, clotting test, live...
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster III Source Type: research
Sarcoidosis is a progressive multisystem disease which is primarily affecting the lungs and is characterized by epithelioid granulomas in various organs and tissues. It is suggested that the severity of sarcoidosis is determined by a violation of endithelial function.Aim: To determine the features of VEGF production during the active course of lung sarcoidosis.Materials and Methods: Twenty three patients with lung sarcoidosis were examined. The VEGF level was determined using ELISA (enzyme-linked immunosorbent assay) and test of R&D systems Kuantykine (USA). Comparisons were made with the morphological data and the results...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
Conclusions: HRCT-scan have limitations if the objective is to accurate define interstitial lung diseases. Consequently, pathological assessing should be taken into account, in order to provide more accurate tailored treatment strategies.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Idiopathic interstitial pneumonias Source Type: research
Conclusions: The prevalence of CS exceeds 20% in extra-CS patients even with normal ECG and Echo. Physicians should keep in mind such an unrecognized population and risk of underdiagnosis of CS.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
This study aimed to evaluate the aforementioned tests, in order to examine the functional capacity of sarcoidosis patients, in different stages.Methods: This cross-sectional study carried out, on 50 Iranian patients with sarcoidosis. Patients were classified into three groups, based on the findings of the chest radiography, as well as the pulmonary CT scan, performed by an expert Radiologist; Pulmonary, cardiac and activity function have been evaluated in the patients, using CPET, 6MWT and spirometry.Results: In CPET, percent-predicted peak VO2, 57.75±15.49, p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
Conclusion: CS therapy is a risk factor for sarcoidosis relapse. Therefore, despite their high efficacy, corticosteroids are recommended in asymptomatic patients only in cases of progressive disease or lack of improvement after 3 months follow-up period.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
We describe a cohort of patients who have evidence of granulomatous inflammation during EBUS-TBNA (endobronchial ultrasound-guided transbronchial needle aspiration) done for the investigation of sarcoidosis and staging of a known lung cancer.Out of 800 EBUS performed between May 2010- Nov 2017, 500 yielded a benign diagnosis (men 55.6%). Rapid on-site evaluation by a cytopathologist was done in 82% of procedures and yielded a diagnosis in 86.8%.In the setting of suspected sarcoidosis (59.3%), the mean diagnostic yield was 61.05%, ATS Station 7 being the most commonly sampled lymph node (66.67%)Granulomatous inflammation wa...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and positron emission tomography (PET) standard uptake values (SUV) are useful methods for evaluating mediastinal lymph node pathology.The aim this study was to compare EBUS TBNA and PET suv results in benign, granulomatous and malignant disease. The files of 151 patients who had FDG-PET scanning and underwent EBUS-TBNA between 2015-2017 were reviewed. The diagnoses were confirmed by needle aspiration cytology, histopathology and clinical follow-up. Malignant diseases included lung cancers, metastasis and lymphomas. Granulomatous diseases were mai...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
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