Radiosynthesis and in vivo evaluation of [11C]MPC-6827, the first brain penetrant microtubule PET ligand

Conclusions: We report the automated radiolabeling procedure for [11C]MPC-6827 with high radiochemical yield, purity and specific activity. In vivo studies in rodents indicated BBB penetration and binding of the radiotracer in brain and other organs. Combination of favorable kinetics and robust specific binding with excellent brain uptake may make [11C]MPC-6827 a suitable PET ligand for the in vivo quantification of MT inside and outside the brain. Lack of a suitable reference region is likely to be due to ubiquitous target distribution instead a specific property of this ligand. Grant support: Diane Goldberg Foundation (NYSPI/CUMC) and WFSM CTSA TIP (UL1TR001420)
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Probes for Neuroimaging Posters Source Type: research