Radiosynthesis and in vivo evaluation of 11CMPC-6827, the first brain penetrant microtubule PET ligand

Conclusions: We report the automated radiolabeling procedure for [11C]MPC-6827 with high radiochemical yield, purity and specific activity. In vivo studies in rodents indicated BBB penetration and binding of the radiotracer in brain and other organs. Combination of favorable kinetics and robust specific binding with excellent brain uptake may make [11C]MPC-6827 a suitable PET ligand for the in vivo quantification of MT inside and outside the brain. Lack of a suitable reference region is likely to be due to ubiquitous target distribution instead a specific property of this ligand. Grant support: Diane Goldberg Foundation (NYSPI/CUMC) and WFSM CTSA TIP (UL1TR001420)
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Probes for Neuroimaging Posters Source Type: research

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Conclusions: The present study demonstrates that hyperpolarized 13C MRS potentially can be used to identify and characterize gliomas that are 18F-FDG negative. The Lac/Bic imaging marker is interesting because it reports on the ratio between increased glycolysis (Warburg effect) and the more ATP favorable oxidative phosphorylation inside the cells3. Further histological analysis will be performed to get better understanding how the metabolic differences correlate with the proliferative state of the tumor. Acknowledgements NIH grants R01CA176836, R01EB019018, P41EB01589, S10OD012283, S10OD018130-01 GE HealthcareLucas Founda...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Multimodality and Nonradioactive Probes Posters Source Type: research
Conclusions: Primary human and mouse T-cells have similar spatial and temporal biodistribution within one week after intravenous injection. Signal is detected mainly in the lungs, liver, spleen, and some in bone. One week after injection, label can be detected in the blood, spleen and bone. This suggest that viable T-cells persist in blood. 89Zr signal in bone and spleen usually indicate free 89Zr binding to bone or expired cells ending up in the spleen. We now have a basis for quantifying efficacy of adoptively transferred T-cells in vivo using PET (89Zr). Reference: 1. Weist, M.R., Starr, R., Aguilar, B., Chea, J., Miles...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology, Basic and Translational (Basic Science) II Source Type: research
In this study, the cerebral-protective effect of crocin was evaluated on a rat transient middle cerebral artery occlusion (MCAO) model. Our data showed that oral administration of crocin had better effectiveness in cerebral protection than an intravenous injection. Neither crocin nor its metabolite crocetin were determined in the brain of cerebral I/R rats, indicating a target site of periphery. Abundant crocetin was detected in plasma after oral administration instead of intravenous injection of crocin. Meanwhile, orally administered crocetin showed similar cerebral protection to that of crocin, but this exciting effect w...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: Magnesium sulfate is an important adjuvant drug in the practice of anesthesia, with several clinical effects and a low incidence of adverse events when used at recommended doses. Introduction Magnesium is the fourth most common ion in the body, and it participates in several cellular processes, including protein synthesis, neuromuscular function and stability of nucleic acid, as well as regulating other electrolytes such as calcium and sodium. Magnesium acts as a cofactor in protein synthesis, neuromuscular function and stability and the function of nucleic acids. It is a component of adenosine 5-triph...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients. Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is increasing in incidence (1). Patients with acute severe TBI (sTBI) often develop severe disorders of consciousness, i.e., coma, minimally conscious state or vegetative state. Although many patients may regain consciousness during the 1-month post-TBI p...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Chiu-Min Lin1†, Ching-Fang Yu2,3†, Hsueh-Ya Huang1,4, Fang-Hsin Chen2,3,5, Ji-Hong Hong2,3,5 and Chi-Shiun Chiang1,6,7* 1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan 2Department of Radiation Oncology, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan 3Radiation Biology Research Center, Institute for Radiological Research, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan 4Education &Medical Research National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan 5Department of Medical Imaging an...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: This study highlights the importance of regular care and patient follow-up. Introduction Status epilepticus (SE) is a condition and most extreme form of epilepsy (1), which leads to abnormal and prolonged seizure (at least 5 min). In case SE persists over 30 min, it may have severe long-term consequences (2). Referring to the new classification scheme of SE, there are two operational dimensions of the definition: time point 1 (T1) is associated with abnormally prolonged seizure, when therapy should be initiated, while time point 2 (T2) is related to the time of on-going seizure activity involving a risk...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Geng-Hong Xia1†, Chao You1,2†, Xu-Xuan Gao1, Xiu-Li Zeng1, Jia-Jia Zhu1, Kai-Yu Xu3, Chu-Hong Tan1, Ruo-Ting Xu1, Qi-Heng Wu1, Hong-Wei Zhou3, Yan He4*‡ and Jia Yin1*‡ 1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China 2Department of Neurology, The First People's Hospital of Zunyi, Zunyi, China 3State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China 4Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical Univ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic an...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study hypothesized that similar VOCs might be detected after HBOT. Methods: Ten healthy volunteers of the Royal Netherlands Navy underwent six HBOT sessions (95 min at 253 kPa, including three 5-min “air breaks”), i.e., on five consecutive days followed by another session after 2 days of rest. At 30 min before the dive, and at 30 min, 2 and 4 h post-dive, exhaled breath was collected and followed by PFT. Exhaled breath samples were analyzed using gas chromatography-mass spectrometry (GC-MS). After univariate tests and correlation of retention times, ion fragments could be identified using a reference data...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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