Proton Range Verification with PET Imaging in Brain and Head and Neck Cancers
Conclusions: Despite the often-complicated geometry and the high washout, it is possible to use profiles to compare measured and expected range differences of proton treatments in the head. We are able to provide an assessment of range differences between PET and MC-PET, and thus planned and delivered dose, across the entire beam cross section. The modified MC parameters for CSF regions made the profile shape of the MC more realistic and improved the comparison with PET. Results of the range comparisons can be used on a patient/fraction basis to check individual fractions, or population basis to determine the overall accuracy achievable for a given beam/anatomical location combination. Increasing the PET signal by reducing the delay between treatment and imaging has the potential to greatly improve the results. In-beam PET systems could provide higher imaging quality for even more accurate comparisons.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Grogg, K., Zhu, X., Shih, H., Alpert, N., El Fakhri, G. Tags: Image Guided Therapy Source Type: research
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