Preparation of 3-[18F]fluoro-2-hydroxypropanoic acid and preliminary tumor PET imaging study

Conclusions: The purification of the intermediate methyl 3-[18F] fluoro-2-hydroxy-propionate using HPLC was essential with the presence of a byproduct methyl 2-[18F] fluoro-3-hydroxy-propionate in the nucleophilic ring opening reaction. Although further optimization of preparation and catabolism of 3-[18F] lactate are required, the preliminary in vivo PET imaging results showed the specific tumor uptake of 3-[18F] lactate. And these findings could be used to inform the development of tumor lactate metabolism imaging agents. Acknowledgements: This work was partly supported by the National Natural Science Foundation (No. 81471695 and 81571716), Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (No. 2014134).
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology III Source Type: research