The potential role of 18F-FDG PET/CT for early response assessment of immune checkpoint inhibitors

Conclusions: Early favorable signs of FDG-PET parameters may vary among diseases with immune checkpoint inhibitors. Mean FDG uptake was elevated in several immune-related organs at the early restaging scan. Among them, elevated FDG accumulation in thyroid might be a candidate sign of monitoring effectiveness of immunotherapy observed earlier than immune-related lymphadenopathy. Relationship between % change () of PET parameters and patients outcome% chage (Î") of PET parametersMalignant melanoma(Odds, 95%CI, p)Malignant lymphoma (Odds, 95%CI, p)Renal cell carcinoma (Odds, 95%CI, p)Î"sum0.962, 0.929-0.996, 0.0280.95, 0.910-0.992, 0.0210.93, 0.858-1.008, 0.077Î"MTVn.a.0.735, 0.507-1.066, 0.1050.994, 0.978-1.010, 0.463Î"TLGn.a.0.624, 0.360-1.083, 0.0940.994, 0.982-1.006, 0.305Î"pituitary0.969, 0.883-1.064, 0.5140.98, 0.934-1.027, 0.3920.934, 0.852-1.024, 0.146Î"tonsil1.084, 0.990-1.188, 0.083 1.04, 0.987-1.095, 0.1390.928, 0.875-0.984, 0.012Î"thyroid0.987, 0.959-1.015, 0.3571.011, 0.991-1.031, 0.289n.a.Î"ileum1.002, 0.994-1.011, 0.598 1.031, 0.977-1.088, 0.2670.998, 0.970-1.026, 0.875Î"spleen1.016, 0.980-1.053, 0.3780.976, 0.908-1.049, 0.5080.947, 0.850-1.054, 0.32Î"spinal marrow0.923, 0.862-0....
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors Source Type: research