The mechanism of global and regional left ventricular mechanical dyssynchrony in a porcine model of acute myocardial infarction assessed by single photo emission computed tomography gated myocardial perfusion imaging

Conclusions: The mechanical dyssynchrony occurs in both the infarct and non-infarct areas. The global LVMD is mainly influenced by the mechanical dyssynchrony in the infract area. The extent of mechanical dyssynchrony in non-infarcted myocardium is closely associated with the abnormality of regional wall thickening and motion, which represents the decreased myocardial contractility. The reduced wall thickening and motion in normal perfusion myocardial segments may be an effective therapeutic target to improve the mechanical dyssynchrony of non-infarcted myocardium.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New Developments: Metabolism, Perfusion and Analysis Methods Source Type: research