F-18 FDG PET/CT for monitoring immunotherapy with PD-1 blockade in patients with advanced non-small cell lung cancer

Conclusion: In this retrospective study of patients with NSCLC treated with PD-1 antibodies, tumor response by standard PERCIST was significantly correlated with OS. Modifications of the PERCIST criteria to account for inflammatory lesions did not substantially improve the prognostic value of tumor response on FDG PET. While these results are promising for the use of FDG PET for monitoring immunotherapy, further studies are warranted to understand the impact of the type of immunotherapy and the timing of the FDG PET scans on response assessment. table 1PERCIST5 (modified)CMRPMRSMDPMDTotalPERCIST1 (modified)CMR70007PMR0102012SMD007714PMD0032023Total710122756
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer II: PET-Derived Parameters as Predictors of Response to Therapy Source Type: research