In vivo monitoring of CAR T cells using [18F]fluoropropyl-trimethoprim
Conclusion Imaging will likely play a central role in understanding immune cell trafficking to tumors, evaluating sites of potential toxicity, and determining the efficacy of cell-based therapies. We show in vivo BLI and PET/CT monitoring of CAR T cells trafficking to solid tumors. This triple reporter imaging approach allows facile monitoring of cells in preclinical studies (via fluorescence and/or BLI), and we anticipate that the [18F]FPTMP/dhfr PET probe and reporter gene pair will be useful for tracking CAR T cells in the clinical setting. Future studies will test whether trafficking of CAR T cells correlates with therapeutic response.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Sellmyer, M., Richman, S., Lohith, K., Hou, C., Lieberman, B., Mankoff, D., Mach, R., Milone, M., Farwell, M. Tags: Center for Therapy Excellence YIA Symposium Source Type: research
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