Dynamic SPECT imaging of 123I-mIBG for early detection of doxorubicin-induced cardiotoxicity in dogs

Conclusion: SPECT dynamic imaging of 123I-mIBG can be used as an effective tool in the early detection of doxorubicin-induced cardiotoxicity, since 123I-mIBG quantification using VT decreased as early as cumulative doxorubicin doses of 3-5 mg/kg and preceded systolic dysfunction as derived by echocardiography. Additional large-animal studies are ongoing to further confirm this conclusion.

Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Wu, J., Boutagy, N., Feher, A., Romito, E., Liu, Z., Lin, S.-f., Gallezot, J.-D., Kapinos, M., Teng, J.-k., Carson, R., Sinusas, A., Liu, C. Tags: Cardiovascular Molecular Imaging: Innervation and Inflammation Source Type: research