Synthesis and evaluation of a novel 18F labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer

Conclusions: We synthesized a novel PARP-1 radioligand, [18F]WC-DZ-F and demonstrated its potential in PET imaging of PARP-1 expression in the PC-3 model of PC by in vitro cell uptake studies, microPET imaging and postPET autoradiography, and biodistribution in normal mice. Further evaluation in other models of PC are warranted. Research Support: NIH: CA25836

Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Zhou, D., Xu, J., Chu, W., Kim, S. H., Rogers, B., Katzenellenbogen, J. Tags: Radiolabeled Small Molecules and New Applications - Oncology Source Type: research