Brain tumor PET imaging in a transgenic medulloblastoma mouse model using a novel 18F- labeled tryptophan tracer

Conclusions: L-1-[18F]FETrp showed clear retention in medulloblastoma tumors of Smo-Smo mice. Our preliminary medulloblastoma tumor tissue analysis indicates high expression of TDO2 enzyme, which suggests the tracer uptake reflects TDO2-mediated KP. These preclinical studies suggest that TDO2 may be a therapeutic target for medulloblastoma and L-1-[18F]FETrp has potential for PET imaging of medulloblastoma.

Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Zhang, S., Dalvi, N., Xin, Y., Litan, A., Yue, X., Li, H., Li, Z., Cai, H., Chugani, H., Langhans, S., Chugani, D. Tags: Radiolabeled Small Molecules and New Applications - Oncology Source Type: research