An 18F-Alanine derivative serves as an ASCT2 marker for cancer imaging
Conclusion: The 18F-Ala-BF3 was successfully synthesized through one-step 18F-19F isotope exchange with fine specific activity and good radiochemical yield. Following in vitro bio-distribution and in vivo PET imaging in gastric tumor xenografts bearing mice and healthy mice revealed high tumor to normal tissue rate consist with fine tumor imaging of 18F-Ala-BF3. This study shed light on ASCT2 as a cancer biomarker for clinical diagnosis, and emphasized the usefulness of BAAs in tumor PET imaging. 18F-Ala-BF3 represents a useful molecular platform for tumor diagnosis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Liu, H., Han, Y., Li, J., Fu, Q., Wang, C., Liu, Z. Tags: Radiolabeled Small Molecules and New Applications - Oncology Source Type: research
More News: Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer Therapy | CT Scan | Gastric (Stomach) Cancer | Gastritis | Gastroenterology | Neurology | Nuclear Medicine | PET Scan | Study | Thyroid | Thyroid Cancer