Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer

Conclusion: These findings underline that variations in the polymethine chain lengths of cyanine dyes have a profound influence on the photophysical properties, stability, and in vivo targeting capabilities of fluorescent imaging tracers. In a direct comparison, the intermediate-length dye (Cy5) yielded a superior c[RGDyK] tracer, compared with the shorter (Cy3) and longer (Cy7) analogs.

Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Buckle, T., van Willigen, D. M., Spa, S. J., Hensbergen, A. W., van der Wal, S., de Korne, C. M., Welling, M. M., van der Poel, H. G., Hardwick, J. C. H., van Leeuwen, F. W. B. Tags: Basic Source Type: research