Immuno-PET in Inflammatory Bowel Disease: Imaging CD4-Positive T Cells in a Murine Model of Colitis

Conclusion: 89Zr-malDFO-GK1.5 cDb detected CD4+ T cells in the colons, ceca, and MLNs of colitic mice and may prove useful for further investigations of CD4+ T cells in preclinical models of IBD, with potential to guide development of antibody-based imaging in human IBD.

Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Freise, A. C., Zettlitz, K. A., Salazar, F. B., Tavare, R., Tsai, W.-T. K., Chatziioannou, A. F., Rozengurt, N., Braun, J., Wu, A. M. Tags: Basic Source Type: research