{alpha}-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies--Part 1

With a short particle range and high linear energy transfer, α-emitting radionuclides demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides that decay by α-particle emission, only a few of these can reasonably be exploited for therapeutic purposes. Factors including radioisotope availability and physical characteristics (e.g., half-life) can limit their widespread dissemination. The first part of this review will explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitters.

Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Poty, S., Francesconi, L. C., McDevitt, M. R., Morris, M. J., Lewis, J. S. Tags: Continuing Education Source Type: research