A “Counter-Enhancer” in Tumor Suppression

Publication date: 31 May 2018 Source:Cell, Volume 173, Issue 6 Author(s): Francesco P. Marchese, Maite Huarte The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor. Teaser The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.
Source: Cell - Category: Cytology Source Type: research