Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway.
Conclusion: These novel findings for direct effects of celecoxib on mitochondria to induce metastatic cancer cell death via a ROS-dependent pro-oxidative mechanism provide supportive evidence for its combinatorial use as a chemosensitizing agent complementing chemotherapies to improve response rates in patients with advanced metastatic cancers.
PMID: 29800556 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Pritchard R, Rodríguez-Enríquez S, Pacheco-Velázquez SC, Bortnik V, Moreno-Sánchez R, Ralph S Tags: Biochem Pharmacol Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Celebrex | Drugs & Pharmacology | Melanoma | Mitochondria | Skin Cancer | Stem Cell Therapy | Stem Cells | Study | Toxicology | Xeloda