[PERSPECTIVES] Treatment of Advanced Prostate Cancer--A Review of Current Therapies and Future Promise

We describe putative predictive biomarkers, including androgen receptor splice variants, phosphatase and tensin homolog (PTEN) loss, homologous recombination repair defects, including BRCA2 loss, and mismatch repair defects. The development of next-generation sequencing techniques and the routine biopsy of metastatic disease have driven significant advances in our understanding of the genomics of cancer, and are now poised to transform our treatment of this disease.

Source: Cold Spring Harbor perspectives in medicine - June 1, 2018 Category: Research Authors: Sumanasuriya, S., De Bono, J. Tags: Prostate Cancer PERSPECTIVES Source Type: research