Wales to host UK ’s first respiratory disease innovation centre

The Welsh government has announced that £2.5m will be invested in a new innovation centre to develop new ways to tackle respiratory disease.
Source: Nursing Times - Category: Nursing Source Type: news

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Authors: Stinner MDJ, Schmidt AH Abstract The 12th Extremity War Injuries Symposium focused on issues related to the transitions in medical care that are occurring as the focus of the war on terror changes. The symposium highlighted the results of Department of Defense-funded research in musculoskeletal injury, the evolution of combat casualty care, and the readiness of the fighting force. Presentations and discussions focused on force readiness of both troops and their medical support as well as the maintenance of the combat care expertise that has been developed during the previous decade of conflict. PMID: 2...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
AbstractAdult-onset Still ’s disease (AOSD) represents a systemic autoinflammatory disease (SAID), and its diagnostic criteria are clinical without genetic testing. Given shared manifestations between AOSD and hereditary SAIDs, molecular analysis may help differentiate these diseases. A PubMed literature search was conduct ed using key words “adult-onset Still’s disease,” “autoinflammatory disease,” and “genetic mutation” between 1970 and February 2018. Articles on genetic mutations in the genes MEFV, TNFRSF1A, mevalonate kinase, or NOD2 for hereditary SAIDs in AOSD/systemic ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Abstract Because of the level of attention it received due to its role as the principal HIV coreceptor, CCR5 has been described as a 'celebrity' chemokine receptor. Here we describe the development of CCR5 inhibitory strategies that have been developed for HIV therapy and which are now additionally being considered for use in HIV prevention and cure. The wealth of CCR5-related tools that have been developed during the intensive investigation of CCR5 as an HIV drug target can now be turned towards the study of CCR5 as a model chemokine receptor. We also summarize what is currently known about the cell biology and p...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Abstract Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. Here we review the role of CXCL4 and CXCL4L1 in cancer, the use of both chemokines as cancer biomarkers and discuss some possible therapeutic opportunities. PMID: 2...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Abstract Accumulating evidence indicates that chemokine-chemokine receptor interactions invoke biological responses beyond their originally described function of orchestrating leukocyte trafficking. In this review we will extend the findings that chemokines participate actively in the neoplastic process, and consider the contribution of CCL5 activation of CCR5 on breast cancer cells to upregulation of anabolic metabolic events that would support the energy demands of cell replication and proliferation. PMID: 29903574 [PubMed - in process]
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Abstract Chemokines are important proteins involved in the regulation of directed leukocyte migration during inflammation and the homeostatic homing of immune cells. In addition, they play a role in angiogenesis, hematopoiesis, organogenesis, tumor growth and metastasis. Therefore, the chemokine/chemokine receptor network is highly complex and needs to be tightly controlled. An important mechanism of fine-tuning chemokine activity and reducing its apparent redundancy is post-translational modification (PTM) of chemokines and their receptors. Under inflammatory conditions, enzymes such as matrix metalloproteinases ...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Abstract The discovery that atypical chemokine receptors (ACKRs) can initiate alternative signaling pathways rather than classical G-protein coupled receptor (GPCR) signaling has changed the paradigm of chemokine receptors and their roles in modulating chemotactic responses. The ACKR family has grown over the years, with discovery of new functions and roles in a variety of pathophysiological conditions. However, the extent to which these receptors regulate normal physiology is still continuously expanding. In particular, atypical chemokine receptor 3 (ACKR3) has proven to be an important receptor in mediating norm...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Abstract The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression, increasing tumor cell survival and chemoresistance and metastasis to organs with high CXCL12 levels (e.g., lymph nodes and bone marrow (BM)). Furthermore, the overexpression of CXCR4 has been found to have prognostic significance for disease progression in ...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
BAD breath is a problem many of us have experienced once. However, we often don ’t notice until other people start leaning away from us. Try these seven tips to eradicate your bad breath.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Thread Starter Medicine foundation programme Follow 1 minute ago now Nope.
Source: The Student Room - Category: Universities & Medical Training Authors: Tags: Medicine Source Type: forums
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