Effect of Exogenous Alpha-B Crystallin on the Structures and Functions of Trabecular Meshwork Cells.

This study, for the first time, focused on the role of CRYAB in undesired changes of the structures and functions in trabecular meshwork (TM) cells. Methods: Cell proliferation and migration were assessed using a cell counting kit-8 (CCK8) and transwell assay analysis, respectively. Immunofluorescence (IF), quantitative real-time PCR (Rt-qPCR), and Western blot were performed to determine the effect of CRYAB on F-actin, tight junctions, and the expression of epithelial to mesenchymal transition- (EMT-) associated proteins in TM cells. Results: CRYAB promoted proliferation (p
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research

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Authors: Yaşa D, Ürdem U, Ağca A, Yildirim Y, Kepez Yildiz B, Kandemir Beşek N, Yiğit U, Demirok A Abstract Purpose: To report clinical results of a foldable, hydrophilic acrylic, single-piece, injectable, posterior chamber phakic intraocular lens (pIOL). Material and Methods: Medical records of patients who underwent posterior chamber phakic IOL (Eyecryl Phakic IOL, Biotech Vision Care, Ahmedabad, India) implantation for surgical correction of myopia were retrospectively reviewed. Only patients with at least a one-year follow-up were included. Manifest refraction, uncorrected distance visual acuity (U...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Glaukos, based in San Clemente, California, won FDA approval to introduce its iStent inject Trabecular Micro-Bypass System in the United States. The device, designed to treat mild to moderate primary open-angle glaucoma, is implan...
Source: Medgadget - Category: Medical Devices Authors: Tags: Ophthalmology Source Type: blogs
Conditions:   Glaucoma;   Ocular Hypertension Intervention:   Sponsors:   Wills Eye;   Allergan;   ASCRS Foundation (American Society of Cataract and Refractive Surgery) Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 6 April 2018Source: Journal of Taibah University Medical SciencesAuthor(s): Sylves Patrick, Chan Hui-Tze, Wan Hitam Wan-Hazabbah, Embong Zunaina, Yaakub Azhany, Ahmad Tajudin Liza-SharminiAbstractManagement of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective uveitis and Vogt–Koyanagi–Harada disease, respectively. A 40-year-old woman presented with bilateral redness...
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
ConclusionAs no significant difference in aqueous humor concentration of selenium was detected between open-angle glaucoma and controls, however, quantile analysis showed differences in quantiles levels for different age ranges in open-angle glaucoma patients, the trace element selenium seemed to be linked to glaucoma disease, yet not in a major role.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Marisse Masis Solano, Shan C. LinAbstractCataract extraction is a safe and effective surgery that has a lowering effect on the intraocular pressure. The specific mechanisms for this effect are still unclear. A direct inflammatory effect on the trabecular meshwork, alteration of the blood aqueous barrier, changes in the ciliary body and mechanical changes of the anterior segment anatomy are the key to understand cataract surgery and it's effects on aqueous humor dynamics. Additionally, with the advent of AS OCT, changes in the anteri...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Publication date: April–June 2018Source: Saudi Journal of Ophthalmology, Volume 32, Issue 2Author(s): Nazimul Hussain, Anjli Hussain, Niaz Ahmad KhanAbstractA 39-year-old lady with past history of vitreoretinal surgery for retinal detachment and cataract surgery with Intraocular lens implantation was diagnosed as uncontrolled glaucoma. She had high myopia. She underwent Trabeculectomy and following which she presented with massive suprachoroidal hemorrhage in the first postoperative day with severe loss of vision. This case depicts the risk of suprachoroidal hemorrhage in a high myopic vitrectomised eye following gla...
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
Publication date: June 2018Source: Journal of American Association for Pediatric Ophthalmology and Strabismus, Volume 22, Issue 3Author(s): Adam J. Cantor, Jingyun Wang, Shanshan Li, Daniel E. Neely, David A. PlagerPurposeTo report the long-term efficacy of endoscopic cyclophotocoagulation (ECP) in pediatric glaucoma following cataract surgery (GFCS).MethodsECP was performed on 35 eyes of 25 patients 24 mm Hg, alternative glaucoma procedure following ECP, or occurrence of visually significant complications. Analysis was performed to estimate risk factors for failure.ResultsA total of 27 aphakic and 8 pseudophakic eyes...
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
ConclusionAs no significant difference in aqueous humor concentration of selenium was detected between open-angle glaucoma and controls, however, quantile analysis showed differences in quantiles levels for different age ranges in open-angle glaucoma patients, the trace element selenium seemed to be linked to glaucoma disease, yet not in a major role.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Publication date: Available online 6 April 2018Source: Journal of Taibah University Medical SciencesAuthor(s): Sylves Patrick, Chan Hui-Tze, Wan Hitam Wan-Hazabbah, Embong Zunaina, Yaakub Azhany, Ahmad Tajudin Liza-SharminiAbstractManagement of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective uveitis and Vogt–Koyanagi–Harada disease, respectively. A 40-year-old woman presented with bilateral redness...
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
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