Effect of Exogenous Alpha-B Crystallin on the Structures and Functions of Trabecular Meshwork Cells.

This study, for the first time, focused on the role of CRYAB in undesired changes of the structures and functions in trabecular meshwork (TM) cells. Methods: Cell proliferation and migration were assessed using a cell counting kit-8 (CCK8) and transwell assay analysis, respectively. Immunofluorescence (IF), quantitative real-time PCR (Rt-qPCR), and Western blot were performed to determine the effect of CRYAB on F-actin, tight junctions, and the expression of epithelial to mesenchymal transition- (EMT-) associated proteins in TM cells. Results: CRYAB promoted proliferation (p
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research

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(Image courtesy of Implandata) Implandata Ophthalmic Products announced that the first patient in its international, multi-center, ARGOS-SC01 clinical study has been successfully implanted with its novel pressure sensor. This first-in-human clinical study is being conducted to validate the suprachoroidally placed Eyemate-SC, a sensor implant for continual monitoring of intraocular pressure (IOP). While Implandata’s already CE-marked Eyemate-IO intraocular sensor implant is intended for use in glaucoma patients undergoing cataract surgery, the Eyemate-SC device allows implantation in glaucoma patients not indicated fo...
Source: Mass Device - Category: Medical Devices Authors: Tags: Blog Optical/Ophthalmic Research & Development Implandata Ophthalmic Products Source Type: news
No abstract available
Source: Journal of Glaucoma - Category: Opthalmology Tags: Online Articles: Letters to the Editor Source Type: research
CONCLUSIONS: Phaco-AIT achieved similar IOP lowering at 6 and 12 months compared with phaco-Trab with a similar number of glaucoma medications required at 1 year, and no serious complications were identified in the Phaco-AIT group. PMID: 30502982 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
The treatment of choice for cases of corneal opacity with significant cataract is often a triple procedure. However, in certain situations the chances of graft survival are poor, for example in cases with deep vascularization, secondary glaucoma, and healed viral keratitis. Under these circumstances, performing cataract surgery only might improve the visual acuity enough to maintain the patient's day-to-day activities. Performing cataract surgery, especially phacoemulsification, in these cases is challenging.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Tags: Review/Update Source Type: research
Purpose of review The aim of this review was to assess the risk factors and course of postoperative intraocular pressure (IOP) increase in order to determine the optimal the treatment. Recent findings Early postoperative IOP elevation following cataract surgery is a frequent adverse event, and might represent 88% early postoperative complications. The risk factors for IOP elevation following phacoemulsification cataract surgery include residual viscoelastic material, resident performed surgery, glaucoma, pseudoexfoliation syndrome, axial length over 25 mm, tamsulosin intake, topical steroid application in steroid re...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: CATARACT SURGERY AND LENS IMPLANTATION: Edited by Natalie A. Afshari Source Type: research
This article reviews canaloplasty indications, results and complications and analyses its outcomes compared with traditional penetrating and non-penetrating techniques.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Conclusions and RelevanceCorneal stiffness is reduced three months following cataract surgery and is associated with falsely low intraocular pressure measurements. This finding may be important for glaucoma patients and in particular when assessing the effectivity of Minimally Invasive Glaucoma Surgery devices.
Source: Clinical and Experimental Ophthalmology - Category: Opthalmology Authors: Tags: Original Article Source Type: research
ConclusionVitrectomy helps lower the PCO risk and reoperation risk after congenital cataract surgery, and also, vitrectomy helps patients gain a better BCVA and achieve a better low ‐contrast sensitivity, with no trade‐off on IOP control, IOL deposit, synechias, uveitis and secondary glaucoma. We recommend performing vitrectomy during congenital cataract surgery.
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Tags: Original Article Source Type: research
To evaluate the long-term safety and efficacy of a trabecular microbypass stent as a sole procedure in pseudophakic eyes with open-angle glaucoma.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Source Type: research
Inflammatory Cytokine Profiles in Eyes with Primary Angle-Closure Glaucoma. Biosci Rep. 2018 Nov 14;: Authors: Wang Y, Chen S, Liu Y, Huang W, Li X, Zhang X Abstract Acute primary angle-closure (APAC) eyes show an early "acute inflammatory" condition, while the inflammation condition has not been fully elucidated in the development of primary angle-closure glaucoma (PACG). To evaluate the roles of inflammatory cytokines in the pathogenesis of PACG, this cross-sectional study involved 40 eyes of 32 PACG patients who required trabeculectomy and 24 eyes o...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
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