Surveillance of influenza and other respiratory viruses in the UK: Winter 2017-18

This report describes influenza activity experienced in UK from week 40, 2017 to week 15, 2018 and includes observations and commentary from the childhood vaccination programme and activity of other seasonal and novel respiratory viruses.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral therapy (cART) are not clear. We obtained LN biopsies before and 10 to 14 days after trivalent seasonal influenza immunization from healthy controls (HCs) and HIV+ volunteers on cART to investigate CD4+ T follicular helper (Tfh) and B cell dynamics by flow cytometry and quantitative imaging analysis. Prior to vaccination, compared with those in HCs, HIV+ LNs exhibited an altered f...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The Avian Influenza A (H5N1) virus is endemic in poultry in Egypt. The winter of 2014/2015 was particularly worrying as new clusters of HPAI A (H5N1) virus emerged, leading to an important number of AI A (H5N1...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
Authors: Sasaki E, Momose H, Hiradate Y, Furuhata K, Mizukami T, Hamaguchi I Abstract Safety evaluation of a human vaccine is critical for vaccine development and for preventing an unexpected adverse reaction in humans. Nonetheless, to date, very few systems have been described for preclinical studies of human adverse reactions in vivo. Previously, we have identified biomarker genes expressed in the lungs for evaluation of influenza vaccine safety, and their usefulness in rodent models and for adjuvant-containing vaccines has already been reported. Here, our purpose was to develop a novel humanized mouse model reta...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
A 30  year old primigravida presented to our emergency department at 20 weeks gestation with rapid onset distal paraesthesia, generalised weakness and motor difficulty. Two weeks prior to the onset, she reported having had the influenza vaccination as recommended in pregnancy. She had no other medical history of note and reported no recent travel. The patient underwent various investigations including lumbar puncture, MRI brain and spine, blood tests including electrolytes, thyroid function, autoimmune antibody screen, HIV, hepatitis and Epstein Barr virus (EBV); all of which were normal.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Correspondence Source Type: research
Conclusions Centralized reminder/recall was effective at increasing influenza vaccination rates in adults aged ≥65 years over a short time period, without burdening the practices, and at a reasonable cost. Trial Registration This study is registered at www.clinicaltrials.gov NCT02133391.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Conclusion: Our literature review suggests that treatment of influenza-infected individuals with Vitamin D supplements or cathelicidin-derived agents may provide appreciable protection against natural influenza infection. Moreover, Vitamin D given at appropriate doses may facilitate protection against seasonal flu.
Source: Current Immunology Reviews - Category: Allergy & Immunology Source Type: research
Each year, influenza viruses bring aches, pains, fever and overall misery to millions of people. The flu also leads to hundreds of thousands of hospitalizations and thousands of deaths. In a new paper published in Genome Medicine, researchers say a blood test may be able to identify which people are more likely to fight off the flu and which may have a harder time. And information from that same test could lead to new treatments — including more effective vaccines — that might make more people more flu-resistant. For four years, Purvesh Khatri, an associate professor of medicine and biomedical data science at S...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news
Conclusion INVESTED is the largest and longest study to assess whether high-dose influenza vaccine is superior to standard-dose influenza vaccine in reducing cardiopulmonary events in a high-risk cardiovascular population (ClinicalTrials.gov Identifier: NCT02787044).
Source: American Heart Journal - Category: Cardiology Source Type: research
ConclusionsWe identifiedKLRD1-expressing NK cells as a potential biomarker for influenza susceptibility. Expression ofKLRD1 was inversely correlated with symptom severity. Our results support a model where an early response byKLRD1-expressing NK cells may control influenza infection.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
Abstract Host jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin-the major capsid protein in influenza A viruses-is subjected to high rate mutations, of which several occur at its "head": the receptor-binding domain that mediates specific binding to host cell receptors. Such surface-changing mutations may lead to antigenically novel influenza A viruses hence in pandemics by host jump and in vaccine escape by antigenic drift. Changes in haemagglutinin surface electrostatics have been re...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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