GSE99995 Whole-transcriptome analysis of tumor tissues of lung adenocarcinoma reveals molecular changes under the influence of IFN- γ

Contributors : Yi Gao ; Lequn Li ; Xiangning FuSeries Type : Expression profiling by arrayOrganism : Homo sapiensIFN- γ is a critical cytokine which regulates both innate and adaptive immune. Ample evidences have elucidated the mechanisms of IFN-γ mediated antitumor effects, including driving T Helper Type 1 (Th1) polarization, activating cytotoxic lymphocyte (CTL) and natural killer T cells, upregulating major h istocompatibility complex class I expression (MHC Class I) in tumor cells, and inhibiting tumor cells proliferation, inducing tumor cells apoptosis. Despite the multiple effects in cancer immune elimination phase (also known as cancer immune surveillance), IFN-γ also effectuates antitumor immunity and protumorigenic activities throughout the cancer immunoediting process including elimination phase and escape phase. One of the most important mechanism elucidating the dual effect of IFN-γ in immunoediting is IFN-γ induced PD-L1 expression in cancer cells. To obtain a detailed molecular apprec iation of what was going on in tumor microenvironment under the influence of IFN-g, we performed global gene expression analysis using the Agilent oligonucleotide microarray system.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research