GSE115165 Whole transcriptome profiling by RNA-sequencing of RNA from N2 and F01D4.5(baf20) C. elegans

Contributors : Alfred L Fisher ; Brett R IpsonSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansA forward genetic screen identified a mutation in the previously uncharacterized gene F01D4.5--homologous with human TCF20 and RAI1--that suppresses the adverse phenotypes observed in m-tyrosine-treated tyrosine aminotransferase mutant C. elegans. To gain insights into the function of F01D4.5. RNA was isolated from N2 and F01D4.5(baf20) mutants and used for whole transcriptome profiling by RNA sequencing. Analysis of the data reveals a signficant reduction in the expression of ribosome protein encoding genes suggesting a diminution in protein synthesis as a compensatory mechansims to abate the adverse effects of m-tyrosine

Source: GEO: Gene Expression Omnibus - June 1, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Caenorhabditis elegans Source Type: research