The novel kinase inhibitor EMD1214063 is effective against neuroblastoma

Conclusions Treatment of neuroblastoma tumor cells with EMD1214063 inhibits HGF-induced c-Met phosphorylation and results in cell death. EMD1214063 treatment is also effective in reducing tumor growth in vivo. EMD1214063 therefore represents a novel therapeutic agent for neuroblastoma, and further preclinical studies of EMD1214063 are warranted.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research