Class III obesity is a risk factor for the development of acute-on-chronic liver failure in patients with decompensated cirrhosis

Acute-on-chronic liver failure (ACLF) is a syndrome that occurs in patients with cirrhosis, characterized by acute hepatic decompensation, organ system failure, and 28-day mortality of greater than 15%.1 The pathophysiology of ACLF has not been fully elucidated, but appears to be a consequence of a dysregulated inflammatory response, resulting in rapidly evolving organ failure and mortality.2 –6 The reported prevalence of ACLF among those hospitalized with decompensated cirrhosis approaches 30%1 and associated healthcare costs of ACLF are as high as $1.7 billion in the US.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research