A Model of Δ9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens

Cannabis is the most widely used illicit drug, but knowledge of the neurological consequences of cannabis use is deficient. Two primary components of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We established a THC+CBD model of self-administration and reinstated drug seeking to determine if, similar to other addictive drugs, cannabis produces enduring synaptic changes in nucleus accumbens core (NAcore) thought to contribute vulnerabilit y to drug reinstatement.

Source: Biological Psychiatry - May 3, 2018 Category: Psychiatry Authors: Sade Spencer, Daniela Neuhofer, Vivian C. Chioma, Constanza Garcia-Keller, Danielle J. Schwartz, Nicholas Allen, Michael D. Scofield, Tara Ortiz-Ithier, Peter W. Kalivas Tags: Archival Report Source Type: research