Pathology of nNOS-Expressing GABAergic Neurons in Mouse Model of Alzheimer ’s Disease

Publication date: 1 August 2018 Source:Neuroscience, Volume 384 Author(s): Seungho Choi, Je-Seong Won, Steven L. Carroll, Balasubramaniam Annamalai, Inderjit Singh, Avtar K. Singh Alzheimer’s disease (AD) is the most common form of dementia that is often accompanied by mood and emotional disturbances and seizures. There is growing body of evidence that neurons expressing γ-aminobutyric acid (GABA) play an important role in regulation of cognition, mood, and emotion as well as seizure susceptibility, but participation of GABAergic neuronal pathology in Alzheimer’s disease (AD) is not understood well at present. Here, we report that transgenic mice expressing human amyloid precursor protein Swedish–Dutch–Iowa mutant (APPSweDI) exhibit early loss of neurons expressing GAD67, a GABA-synthesizing enzyme, in advance of the loss of pyramidal neurons in hippocampal CA1 region. The loss of GAD67+ neurons in APPSweDI mice accompanied with decreased spatial cognition as well as increased anxiety-like behaviors and kainic acid-induced seizure susceptibility at early phase. In the hippocampal CA1 region, GAD67+ neurons expressed high basal levels of neuronal nitric oxide synthase (nNOS) and nitrosative stress (nitrotyrosine). Similarly, GAD67+ neurons in primary cortical and hippocampal neuron cultures also expressed high basal levels of nNOS and degenerated in response to lower Aβ concentrations due to their high basal levels of nitrosative stress. Giv...
Source: Neuroscience - Category: Neuroscience Source Type: research

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What to do when dementia patient refuses care.By Bob DeMarcoAlzheimer's Reading RoomOne of the biggest problems we face as caregivers isHow to get an Alzheimer's Patient to cooperate.In order to get an Alzheimer's Patient to cooperate you need to make some changes in the way you communicate.If you continue to try and explain why you want cooperation you are usually using too many words.Trying to convince a person living with dementia rarely works.Instead of convincing you need to learn how to use fewer words; and,how to guide your loved one.Here are 7 good articles that should help you accomplish this mission.Subscribe to ...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care home alzheimer's cooperation care of dementia patient dementia care how to get cooperation Source Type: blogs
Authors: Becker E, Orellana Rios CL, Lahmann C, Rücker G, Bauer J, Boeker M Abstract BACKGROUND: The aetiology of dementia is not yet fully understood. Stress can have a damaging effect on brain health. The prognostic effect of anxiety is still unclear regarding Alzheimer's disease as well as vascular dementia.AimsTo explore the association between anxiety and future dementia. METHOD: Medline, PsycINFO, CINAHL, Web of Science and ALOIS were searched for publications up to 12 January 2018. Longitudinal studies with a follow-up of at least 2 years were included, if the trait or state anxiety had been assesse...
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Authors: Becker E, Orellana Rios CL, Lahmann C, Rücker G, Bauer J, Boeker M PMID: 30334505 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
The objective of the current pilot study is to explore the feasibility of a trial investigating the impact of computerized cognitive training, yoga, and an active control intervention (wellness education) in individuals with aMCI by conducting a group-randomized, multisite, parallel, three-arm pilot study. We will establish preliminary effect sizes regarding the association of each intervention with neuroimaging and cognitive and participant-reported measures. We also aim to estimate the strength of association between the various outcomes. The current trial aims to recruit 75 people with aMCI and their 75 cognitively heal...
Source: Trials - Category: Research Source Type: clinical trials
This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionThese results suggest that combined treatment ofyokukansankachimpihange with donepezil has a positive clinical effect on improving the behavioral abnormalities, despite the lack of any effect on cognitive functions. Improvements in the diurnal rhythm may improve affective disturbance and anxiety. Thus,yokukansankachimpihange is considered to have a mild stabilizing effect on emotion.
Source: Neurology and Therapy - Category: Neurology Source Type: research
This article originally appeared on Kaiser Health News (KHN), a nonprofit news service covering health issues. It is an editorially independent program of the Kaiser Family Foundation that is not affiliated with Kaiser Permanente.
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news
People with dementia move backwards in time, and may no longer recognize their current selves in mirrors (or any reflective surfaces, like inside windows at night-time).by Rita JablonskiAlzheimer's Reading RoomSome people “friend” themselves (seeWhen Alzheimer's Patients Friend Themselves).They happily talk to and interact with their reflection.Other people become upset when they see a stranger staring at them in the mirror.Article -Dementia Patients are People TooSubscribe to the Alzheimer's Reading RoomEmail:Reflections can cause paranoia or accusations of infidelity arise.Has your loved one everaccused you o...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's Alzheimers Dementia care of dementia patients caregiving coping coping with alzheimers help alzheimer's help with dementia care mirrors Source Type: blogs
I must remind myself that the hard to comprehend behaviors being expressed by a person living with Alzheimer's are part of the disease, and are not a deliberate bad act on the their part.It is difficult to describe the range of emotions an Alzheimer's caregiver might feel or experience in a single day.Imagine being happy and then sad, caring then angry, focused then frustrated --an almost endless stream of feelings and emotions that conflict.What ’s the Difference Between Alzheimer’s and DementiaBy Bob DeMarcoAlzheimer's Reading RoomThe caregiver often lives an anxiety filled life day-after-day.Alzheimer's Ange...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer patient alzheimers help care for alzheimers dementia care dementia help for caregivers help alzheimer's help with dementia care memory care facility Source Type: blogs
This article explains what I was thinking on this issue.Alzheimer's Communication Tip -- Touching Foreheads and KindnessOver time I finally realized that usingtoo many words only confused my mother and often lead to her beinganxious, confused and angry.In Alzheimer's World if you use too many words all you are really saying is Blah, Blah, Blah - Blah Blah.An Alzheimer's Communication Tip - No More Blah Blah BlahThebottom line as I see it. Instead of making it all aboutyou, start looking at the worldfrom the view of the person living with dementia. As a result of Alzheimer's or a related dementiathey see and hear things dif...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care Alzheimer's Dementia dementia care dementia help for caregivers family caregiving help alzheimer's help with dementia care memory care searches related to dementia care Source Type: blogs
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