Pathology of nNOS-Expressing GABAergic Neurons in Mouse Model of Alzheimer ’s Disease

Publication date: 1 August 2018 Source:Neuroscience, Volume 384 Author(s): Seungho Choi, Je-Seong Won, Steven L. Carroll, Balasubramaniam Annamalai, Inderjit Singh, Avtar K. Singh Alzheimer’s disease (AD) is the most common form of dementia that is often accompanied by mood and emotional disturbances and seizures. There is growing body of evidence that neurons expressing γ-aminobutyric acid (GABA) play an important role in regulation of cognition, mood, and emotion as well as seizure susceptibility, but participation of GABAergic neuronal pathology in Alzheimer’s disease (AD) is not understood well at present. Here, we report that transgenic mice expressing human amyloid precursor protein Swedish–Dutch–Iowa mutant (APPSweDI) exhibit early loss of neurons expressing GAD67, a GABA-synthesizing enzyme, in advance of the loss of pyramidal neurons in hippocampal CA1 region. The loss of GAD67+ neurons in APPSweDI mice accompanied with decreased spatial cognition as well as increased anxiety-like behaviors and kainic acid-induced seizure susceptibility at early phase. In the hippocampal CA1 region, GAD67+ neurons expressed high basal levels of neuronal nitric oxide synthase (nNOS) and nitrosative stress (nitrotyrosine). Similarly, GAD67+ neurons in primary cortical and hippocampal neuron cultures also expressed high basal levels of nNOS and degenerated in response to lower Aβ concentrations due to their high basal levels of nitrosative stress. Giv...
Source: Neuroscience - Category: Neuroscience Source Type: research

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DiscussionCOPD is known to be associated with the development of cognitive deficits, in particular, regarding for executive functions and attention, memory and logical reasoning. In this context, MMSE has a low diagnostic accuracy to underline effective cognitive impairment in AD-COPD. Our study shows a higher frequency of frontal deficits and behavioral disturbances in patients with AD and COPD than patients with AD-only. COPD could complicate the management of AD patients, thus necessitating a closer and multidisciplinary monitoring.
Source: Neurological Sciences - Category: Neurology Source Type: research
The drink made genetic changes to microglial cells, degrading their functioning. → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia subscribers-only Source Type: blogs
Dr. Rita A. Jablonski is one of the most knowledgeable and experienced persons I know when it comes to memory care, dementia and caregivers.I forwarded Rita a question from one of our readers."How Often Should You Visit a Memory Care Patient When They First Go In"?This is an important question, and is often a great source of anxiety for Alzheimer's caregivers.The answer often depends on the actual circumstances at the time.Topic -Memory CareBy Rita A. JablonskiAlzheimer's Reading RoomSubscribe to the Alzheimer's Reading RoomEmail:Hi, Bob.The answer depends on the physical and mental condition of both parties. Som...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer care Alzheimers Dementia care of dementia patients dementia care help alzheimers help dementia memory care nursing home senior care Source Type: blogs
"The research could soon be translated to the clinic, to human patients with Alzheimer's disease." → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
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Major depressive disorder in patients aged 70 or older is associated with a poorer prognosis than in younger people Related items fromOnMedica New evidence on benzodiazepine link to Alzheimer ’s Anxiety in midlife linked to risk of later dementia Suicide no more likely in men on 5 α-reductase inhibitors Antidepressants differ in effect on weight gain Doctors debate long-term use of psychiatric drugs
Source: OnMedica Latest News - Category: UK Health Source Type: news
Are persons afflicted with dementia inherently mean?The answer is no, and studies prove it.What can you do?1.Look for patterns of bad behavior, and when they are happening.2.Establish a dailyroutine.3.Introduce activities into your day thatkeep dementia patients occupied.The Alzheimer's Caregiver Blame GameBy Bob DeMarcoAlzheimer's Reading RoomSubscribe to the Alzheimer's Reading RoomEmail:1. Identify the Patterns of BehaviorOne of the most effective things I did as a caregiver isstart keeping track (writing down) thenegative episodes that my mother would perform each day.I started to realize that many of these difficult b...
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At least 5 million Americans are living with Alzheimer's. → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
An estimated 5.4 million Americans carry a diagnosis of Alzheimer's disease or related dementias (ADRD), and the prevalence is projected to increase to 13.8 million by mid-century with the aging of our population.1 Symptoms of ADRD including agitation, anxiety, apathy, and depression reduce a person's quality of life and increase caregiver burden. Specifically in assisted living facilities (ALF), persons with ADRD can create increased workload for staff with mood changes manifesting as resisting necessary care, verbal outbursts, attempts to leave the facility, or physical aggression.
Source: Geriatric Nursing - Category: Nursing Authors: Source Type: research
This study set out to examine amechanism that activates the attentional network in the salience region of the brain.The results offer a new way to approach anxiety, depression and agitation in patients with dementia.Learn More -Alzheimer's Care Anger, Frustration, and AgitationActivation of neighboring regions of the brain may also offer opportunities to delay the continued decline caused by the disease.The StudyFor three weeks, the researchers helped participants select meaningful songs and trained the patient and caregiver on how to use a portable media player loaded with the self-selected collection of music.“When...
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New research suggests that moderate to severe anxiety in midlife may be an independent risk factor for developing dementia in old age.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
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