Gemcitabine resistance mediated by ribonucleotide reductase M2 in lung squamous cell carcinoma is reversed by GW8510 through autophagy induction

In conclusions, GW8510 can reverses gemcitabine resistance in LSCC cells through RRM2 downregulation-mediated autophagy induction, and GW850 may be a promising therapeutic agent against LSCC as it combined with gemcitabine.

Source: Clinical Science - May 31, 2018 Category: Biomedical Science Authors: Chen, P., Wu, J.-N., Shu, Y., Jiang, H.-G., Zhao, X.-H., Qian, H., Chen, K., Lan, T., Chen, C.-G., Li, J. Tags: PublishAheadOfPrint Source Type: research