Anti-mycobacterial haliclonadiamine alkaloids from the Okinawan marine sponge Haliclona sp. collected at Iriomote Island

Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Delfly B. Abdjul, Akiho Yagi, Hiroyuki Yamazaki, Ryota Kirikoshi, Ohgi Takahashi, Michio Namikoshi, Ryuji Uchida Two new haliclonadiamine derivatives, halichondriamine C (1) and 1-epi-halichondriamine C (2), were isolated from the Okinawan marine sponge Haliclona sp. together with known haliclonadiamine (3) and papuamine (4). The structures of 1 and 2 were elucidated based on their spectroscopic data by comparisons with those for related compounds. Compounds 1 and 2 were epimers of each other at the C-1 position. Compounds 1–4 inhibited the growth of Mycobacterium smegmatis and M. bovis BCG and exhibited antibacterial activities against M. avium and M. intracellulare as pathogens of M. avium complex (MAC) disease. Graphical abstract

Source: Phytochemistry Letters - May 31, 2018 Category: Chemistry Source Type: research