Functional Implications of Sexual Dimorphism of Transporter Patterns along the Rat Proximal Tubule: Modeling and Analysis.

Functional Implications of Sexual Dimorphism of Transporter Patterns along the Rat Proximal Tubule: Modeling and Analysis. Am J Physiol Renal Physiol. 2018 May 30;: Authors: Li Q, McDonough AA, Layton HE, Layton AT Abstract The goal of this study is to investigate the functional implications of the sexual dimorphism in transporter patterns along the proximal tubule. To do so, we have developed sex-specific computational models of solute and transport in the proximal convoluted tubule of the rat kidney. The models account for the sex differences in expression levels of the apical and basolateral transporters, in single-nephron glomerular filtration rate, and in tubular dimensions. Model simulations predict that 70.6 and 38.7% of the filtered volume is reabsorbed by the proximal tubule of the male and female rat kidneys, respectively. The lower fractional volume reabsorption in female can be attributed to their smaller transport area and lower aquaporin-1 expression level. The latter also results in a larger contribution of the paracellular pathway to water transport. Similar fractions (70.9 and 39.2%) of the filtered Na+ are reabsorbed by the male and female proximal tubule models, respectively. The lower fractional Na+ reabsorption in female is due primarily to their smaller transport area and lower Na+/H+-exchanger (NHE3) and claudin-2 expression levels. Notably, unlike most Na+ transporters, whose expression levels are lower in female, Na+/glucose cotr...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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