Mechanistic Target of Rapamycin (mTOR): Integrating Growth Factor and Nutrient Signaling in the Collecting Duct.

Mechanistic Target of Rapamycin (mTOR): Integrating Growth Factor and Nutrient Signaling in the Collecting Duct. Am J Physiol Renal Physiol. 2018 May 30;: Authors: Brown A, Fluitt MB, Ecelbarger CM Abstract The renal collecting duct and other post-macula densa sites are the primary tubular regions for fine-tuning of electrolyte homeostasis in the body. A role for the mechanistic target of rapamycin (mTOR), a serine-threonine kinase, has recently been appreciated as playing a central role in this regulation. mTOR exists in two distinct multi-protein functional complexes, i.e., mTORC1 and mTORC2. Upregulation of mTORC1, by growth factors and amino acids, is associated with cell cycle regulation and hypertrophic changes in the cell. In contrast, mTORC2 has been demonstrated to have a role in regulating sodium and potassium reabsorptive processes, including those downstream of insulin and serum-and-glucocorticoid-regulated kinase (SGK). In addition, mTORC2 can upregulate mTORC1. A number of elegant in vitro and in vivo studies using cell systems and genetically-modified mice have revealed mechanisms underlying activation of the epithelial sodium channel (ENaC) and the renal outer medullary potassium channel (ROMK) by mTORC2. Overall, mTOR in its systematic integration of phosphorylative signaling facilitates the delicate balance of whole-body electrolyte homeostasis in the face of changes in metabolic status. Thus, inappropriate regulation of renal mTOR has ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Conclusion: The results of this randomised controlled trial with assessment of blood pressure and same-day self-reports will provide patients a tool to understand the interplay between blood pressure and lifestyle applicable to primary health care. The self-management support system may be of importance for improved adherence to treatment and persistence to treatment recommendations. PMID: 31814476 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Publication date: Available online 11 December 2019Source: Life SciencesAuthor(s): Qingting Wang, Wenhua Shi, Qianqian Zhang, Wei Feng, Jian Wang, Cui Zhai, Xin Yan, Manxiang LiAbstractAimsIt has been shown that up-regulation of E3 ubiquitin ligase seven-in-absentia-homolog 2 (Siah2) and activation of Hippo signaling pathway effector yes-associated protein (YAP) are involved in the development of pulmonary arterial hypertension (PAH). However, it is still unclear whether Siah2 activates YAP in MCT-induced PAH rat model.Main methodsIntraperitoneal injection of monocrotaline (MCT) was used to induce PAH rat models. The right...
Source: Life Sciences - Category: Biology Source Type: research
In this study, N-methylated peptide inhibitors F-N(Me)H-L, V-N(Me)F-R and R-N(Me)V-Y were synthesized against ACE, NEP and APN respectively, using their respective physiological substrates. F-N(Me)H-L inhibited ACE activity with an IC50 of 83 nmol/L, V-N(Me)F-R inhibited NEP activity with an IC50 of 1.173 μmol/L and R-N(Me)V-Y inhibited APN activity with an IC50 of 3.94 nmol/L respectively. Further, the anti-hypertensive effect of N-methylated peptides was evaluated using rat model of dexamethasone-induced hypertension. Individual peptides and their cocktail treatment were started from day 6 of the ...
Source: Peptides - Category: Biochemistry Source Type: research
Conditions:   Pulmonary Artery Hypertension;   Right Ventricular Dysfunction Intervention:   Procedure: Temporary right ventricular pacing Sponsor:   University of California, San Francisco Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Chronic Obstructive Pulmonary Disease (COPD;   Arterial Hypertension;   Diabetes Mellitus Interventions:   Other: ANM;   Other: Placebo Sponsor:   Andalusian School of Public Health Recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: Available online 11 December 2019Source: Pregnancy HypertensionAuthor(s): Anisha R. Bouter, Johannes J. DuvekotAbstractBackgroundIn 2018/2013 both ISSHP and ACOG revised their original statements and postulated new criteria for preeclampsia with and without severe features. Most importantly, preeclampsia can now also be established in the absence of proteinuria when other specific symptoms are present.ObjectiveWhat is the clinical impact of the use of three different new definitions for the diagnosis of preeclampsia?Study designRetrospective cohort study of all pregnant women who gave birth in the Erasmus...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
HIGH blood pressure is prevalent in the UK, with more than one in four people living with it. The condition is often dubbed the “silent killer” because symptoms rarely show up until it is serious so it is important to take steps to keep your blood pressure in check. Diet plays a key role in controlling blood pressure, with certain foods shown to provide particular blood pressure-lowering benefits, including a breakfast s taple.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Teragaki M, Yamamoto T, Hosomi K, Tada Y, Maeda K, Nishiya D, Miyazaki C, Takagi Y, Sakanoue Y, Nishida Y, Okuno H, Tsuiki M, Naruse M Abstract A 46-year-old woman complained of a 10-year history of headache, nausea, a precordial oppressive feeling and shortness of breath on miction. She had noted a marked elevation in her blood pressure after miction using home blood pressure measurement. Her catecholamine levels were less than twice the value of the normal upper limit. Several imaging modalities detected a urinary bladder tumor, and 123I- metaiodobenzylguanidine (MIBG) scintigraphy showed positive accumu...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
(Queensland University of Technology) A drug used to treat high blood pressure may alleviate anxiety induced by long-term heavy alcohol use, and also halt the damage such drinking can cause to the brain's ability to grow new cells, research by Queensland University of Technology (QUT) in Australia shows.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsComputational measures reflecting individual PVS size, length and width were more strongly associated with WMH, stroke and hypertension than computational count or visual PVS score. Multidimensional computational PVS metrics may increase sensitivity to detect associations of PVS with risk exposures, brain lesions and neurological disease, provide greater anatomic detail and accelerate sunderstanding of disorders of brain fluid and waste clearance.Graphical abstract
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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