Shire to pay $59M to settle lawsuits over false drug claims

Drug company Shire has agreed to pay $59.4 million to various states for making a host of unsupported claims regarding five of its drugs for attention deficit hyperactivity disorder and ulcerative colitis. Under the settlement, announced Wednesday, the company admits no wrongdoing despite charges that it claimed its ADHD drug Adderall XR can help “poor academic performance, loss of employment, criminal behavior, traffic accidents and sexually transmitted disease,” according to the federal Department…
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: research

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Publication date: Available online 16 November 2019Source: Redox BiologyAuthor(s): Solveigh C. Koeberle, André Gollowitzer, Jamila Laoukili, Onno Kranenburg, Oliver Werz, Andreas Koeberle, Anna P. KippAbstractGlutathione peroxidase 2 (GPx2) is one of the five selenoprotein GPxs having a selenocysteine in the active center. GPx2 is strongly expressed in the gastrointestinal epithelium, as is another isoform, GPx1, though with a different localization pattern. Both GPxs are redox-active enzymes that are important for the reduction of hydroperoxides.Studies on GPx2-deficient mice and human HT-29 cells with a stable k...
Source: Redox Biology - Category: Biology Source Type: research
Authors: Naftali T PMID: 31713366 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
AbstractCalotropis procera (CP; Apocynaceae) is reported to have several neuroprotective activities however it ’s anti-depressant activity yet to be established. Therefore, the present study was proposed to evaluate the anti-depressant activity of the standardized ethanolic extract of CP (ECP) in chronic unpredictable mild stress (CUMS) paradigm exposed male rats. Animals were exposed to CUMS from day-1 (D -1) to D-28 except control group animals of the experimental schedule. ECP (50, 100 and 200 mg/kg, p.o.) and Imipramin (15.0 mg/kg, p.o.) were administered for seven consecutive days after CUMS paradigm. ...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
CONCLUSIONS: the prevalence of CeD in our patients with IBD was higher than that reported in the literature for other series of patients with IBD. A combination of anti-tTG testing and CeD genetics may screen patients for CeD in this population of patients with IBD. PMID: 31718200 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
CONCLUSION: Patients showed a good response to a seton procedure combined with IFX therapy regardless of the time of initiation of IFX therapy. PMID: 31726000 [PubMed]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Authors: Lee JL PMID: 31725995 [PubMed]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Publication date: Available online 15 November 2019Source: Autoimmunity ReviewsAuthor(s): José María G. Ruiz de Morales, Lluís Puig, Esteban Daudén, Juan D. Cañete, José Luis Pablos, Antonio Olveira Martín, Carlos González Juanatey, Alfredo Adán, Xavier Montalbán, Natalia Borruel, Guillermo Ortí, Esther Holgado Martín, Carolina García-Vidal, Cynthia Vizcaya Morales, Víctor Martín Vázquez, Miguel Ángel González-GayAbstractInterleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ConclusionThis is the first report in the literature of a causative relation between methylphenidate and the development of SSc, a serious, life-threatening condition. Patients treated with CNS stimulants should be followed closely for side-effects such as RP and skin changes.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: 14 November 2019Source: Cell, Volume 179, Issue 5Author(s): Bing Huang, Zhanghua Chen, Lanlan Geng, Jun Wang, Huiying Liang, Yujie Cao, Huan Chen, Wanming Huang, Meiling Su, Hanqing Wang, Yanhui Xu, Yukun Liu, Bingtai Lu, Huifang Xian, Huiwen Li, Huilin Li, Lu Ren, Jing Xie, Liping Ye, Hongli WangSummaryPediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the growth of infants and children, but the etiopathogenesis underlying disease subtypes remains incompletely understood. Here, we report single-cell clustering, immune phenotyping, and risk gene analysis for chil...
Source: Cell - Category: Cytology Source Type: research
Conditions:   Ulcerative Colitis;   Telemedicine Intervention:   Device: Constant-Care Sponsors:   Nordsjaellands Hospital;   Calpro AS Recruiting
Source: - Category: Research Source Type: clinical trials
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